卡维地洛联合曲美他嗪治疗风湿性心脏病伴慢性心力衰竭的效果观察

The Effect Observation of Carvedilol Combined with Trimetazidine in the Treatment of Rheumatic Heart Disease with Chronic Heart Failure

目的探讨卡维地洛联合曲美他嗪治疗风湿性心脏病伴慢性心力衰竭的疗效。方法将我院收诊的156例风湿性心脏病伴慢性心力衰竭患者随机分成两组,各78例。对照组采用强心、利尿、舒血管等常规治疗,观察组在对照组治疗的基础上采用卡维地洛联合曲美他嗪治疗。治疗6个月后,比较两组患者的心功能疗效差异;比较治疗前,治疗第3、6个月时两组患者射血分数、六分钟步行距离及心力衰竭症状评分。结果治疗6个月后观察组总有效率为69.2%,对照组总有效率为46.2%,两组疗效比较,差异有统计学意义(P<0.05)。治疗前两组患者射血分数、六分钟步行距离及心力衰竭症状评分比较,差异无统计学意义(P>0.05)。用药3个月时,观察组患者六分钟步行距离改善情况优于对照组,差异有统计学意义(P<0.05)。用药6个月时,观察组患者射血分数、六分钟步行距离及心力衰竭症状评分改善情况优于对照组,差异有统计学意义(P<0.05)。结论卡维地洛联合曲美他嗪能有效提高基础方案治疗心力衰竭的疗效,改善心力衰竭的各项症状。

Objective To investigate the efficacy of carvedilol combined with trimetazidine in the treatment of rheu- matic heart disease with chronic heart failure. Methods The diagnosis of 156 eases of rheumatic heart disease in patients with chronic heart failure were randomly divided into two groups, each of 78 cases. After 6 months of treatment, compared two groups of patients with heart function effect; before treatment, treatment 3, 6 months, two groups of patients with ejection fraction, six minutes walking distance and heart failure symptom score. Results After 6 months of treatment, the total effective rate of observation group was 69. 2%, the total effieieney of control group was 46. 2%, compared with two groups of eurative effect, the difference was statistically significant （P 〈 0. 05 ）. After 3 months, patients in the Observation group six minutes walking dis- tance to improve the situation better than the control group, the difference was statistically significant （ P 〈 0. 05 ）. After 6 months, patients in the observation group ejection fraction, six minutes walking distance and heart failure symptom score improvement is better than that of the control group, the difference was statistieally signifieant （ P 〈 0. 05 ）. Conclusion Carvedilol combined with trimetazidine can effectively improve the efficacy of the foundation program in the treatment of heart failure and improve the symptoms of heart failure.