东垣升阳益胃法对类风湿关节炎治疗增效减毒作用

Clinical Study of Dongyuan Shengyangyiwei method in the treatment of rheumatoid arthritis

目的观察升阳益胃法对类风湿关节炎(RA)治疗过程中增效减毒的作用。方法选择诊断明确的150例类风湿关节炎患者,随机分为对照组75例、治疗组75例,均给予甲氨蝶呤、尼美舒利、甲泼尼龙口服,治疗组加用升阳益胃汤加减,对照组加用泮托拉唑钠胶囊,观察90d后对两组胃黏膜损伤及上消化道症状发生率进行比较,并分别在治疗前及治疗后30 d、治疗后90 d观察患者的ALT、ESR、CRP。结果治疗90 d后,治疗组胃黏膜损伤及上消化道症状发生率明显低于对照组,两组差异有统计学意义(P<0.05);两组治疗前后ALT、ESR及CRP比较,治疗组明显好于对照组,差异均有统计学意义(P<0.05)。结论升阳益胃汤能有效防治RA治疗过程中出现的消化系统副作用,同时对类风湿关节炎在改善症状、控制疾病进展等方面具有较好的疗效。

Objective To observe the process of treatment and the role of attenuated effects in the rheumatoid arthritis （RA） treatment with Shengyangyiwei method. Methods 150 patients with RA were randomly divided into two groups. 75 patients in the control group while 75 patients in the treatment group. Both groups were treated with Methotrexate Nimesulide and methylprsdnisone, while the former was added with pantoprazole sodium capsules, and the later was added with Shengyangyiwei Tang treatment. The gastric mucosal injury and gastrointestinal symptoms were observed respectively before treatment and after treatment for 30 d and 90 d. ALT, ESR, CRP of the patients were observed after treating for 30 d and 90 d. Results After 90days＇ treatment, the gastric mucosal injury and gastrointestinal symptoms in the patients of the experimental group were significantly lower than that of the control group.Therefore, the differences of the total efficiency in both groups were statistically significant. （With P〈0.05）. As for ALT, ESR and CRP comparison, the results of the treatment group was significantly better than that of the control group, the differences were significant （P〈0.05）. Conclusion The Shengyangyiwei Tang can effectively prevent and control the digestive side effects in RA therapy and with significant treatment effects, at the same time it has good curative effects to improve symptoms, control the disease progress etc.