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HPLC法测定帕拉米韦的含量及其有关物质 被引量：3

Determination of Peramivir and Its Related Substances by HPLC
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摘要 建立帕拉米韦含量及有关物质的HPLC测定方法。色谱柱:Agilent Zorbax SB C18(250 mm×4.6 mm,5μm);流动相:含0.1%三乙胺的0.005 mol·L-1磷酸二氢钾溶液(pH 6.0)-乙腈(93∶7);检测波长:210 nm。 An HPLC method was established for the determination of peramivir and its related substances. The separation was performed on an Agilent Zobax SB Cls （250 mm×4.6mnl,5μm） column. The mobile phase consisted of 0.1% triethylamine and 0.005 mol .L-1 potassium dihydrogen phosphate solution （adjust to pH 6.0）-acetonitrile （93：7）. The detective wavelength was 210nm. The flow rate was 1.0mL.min-1.
作者 晋欣 王志强 杭太俊 张仓
机构地区 中国药科大学药物分析教研室 南京圣和药业有限公司
出处 《药学与临床研究》 2013年第2期140-142,共3页 Pharmaceutical and Clinical Research
关键词 HPLC法 帕拉米韦 含量测定 有关物质 HPLC Peramivir Content determination Related substances
分类号 R927.2 [医药卫生—药学]
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  • 5Li Y, Zhang XZ, Zhang ZQ, et al. Quantification of peramivir ( a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry [J]. J Chromatogr B, 2009,877( 10): 933-938.
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药学与临床研究
2013年 第2期

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