小檗碱保护糖尿病大鼠肾脏的系统评价

A systematic review of the berberine in protecting kidneys of diabetic rats

目的:从循证医学的角度系统评价小檗碱对糖尿病大鼠肾脏的保护作用。方法:计算机及手工检索相关文献,由2名研究者按纳入与排除标准独立选择实验、交叉核对,评价质量、提取数据,并用RevMan5.0软件对数据进行分析。结果:共纳入5个实验研究,与正常组比较,模型组的相对肾重大(MD=-1.23,95%CI[-1.92,-0.54],Z=3.50,P=0.0005),说明糖尿病大鼠肾脏病变模型成功;与模型组比较,小檗碱组可以减轻大鼠的相对肾重(MD=0.66,95%CI[0.19,1.13],Z=2.74,P=0.0006),减少24h尿蛋白量(MD=35,95%CI[21.76,48.25],Z=5.18,P<0.00001),降低血肌酐(MD=41.09,95%CI[19.70,62.49],Z=3.76,P=0.0002),降低血糖(MD=11.47,95%CI[6.42,16.51],Z=4.45,P<0.00001),从而保护肾脏。结论:小檗碱可以保护糖尿病大鼠肾脏,延缓糖尿病大鼠肾损害进程。

Objective： Systematic review of the berberine in protecting kidney of diabetic rats by evidence-based medicine. Methods： According to the into and exclusion standards, searching the related papers by computers and hands to independently choose experiments, cross-check, evaluate the qualities, extract and analyze the data by RevMan 5.0 software by two researchers. Results： Five experimental researches were fit into the study. The rats in model groups had relative lager kidney weights than the rats in control groups （MD=-l.23, 95%CI[-1.92, -0.54], Z=3.50, P=0.0005）, which showed that the model of kidney damage was success. Compared with model group, Berberine group could relatively decrease the kidney weights （MD=0.66, 95%CI[0.19, 1.13], Z=2.74%, P=0.0006） and reduce 24hours of urine protein （MD=35, 95%CI[21.76, 48.25], Z=5.18, P〈0.00001）, and serum creatinine （MD=41.09, 95%CI[19.70, 62.49], Z=3.76%, P=0.0002）, blood sugar （MD=I 1.47, 95%CI[6.42, 16.51], Z=4.45, P〈0.00001）, which could protect the kidneys. Conclusion： Berberine could protect the kidneys in diabetic rats, delay kidney damage processes.