老年急性冠脉综合征患者血清内脂素水平的变化及意义

Changes in serum visfatin levels in elderly patients with acute coronary syndrome and its significance

目的:分析血清内脂素在老年急性冠脉综合征患者中的表达情况,并探讨血清内脂素与老年冠心病患者冠状动脉病变程度的关系。方法 :选取78例急性冠脉综合征患者作为研究对象,35例经冠脉造影排除冠心病的健康老年人作为对照组(C组),按照急性冠脉综合征的类型分为A组(ST段抬高型)、B组(非ST段抬高型)。结果:B组(非ST段抬高组)血清内脂素水平高于A组(ST段抬高组),A组和B组血清内脂素水平均高于C组,内脂素与冠状动脉病变支数、Gensini积分呈正相关关系(r=0.496、0.752,P<0.01)。结论:老年急性冠脉综合征患者中,血清内脂素水平能够初步反映冠脉病变支数和病变程度;血清内脂素可能在老年急性冠脉综合征的发生、发展中产生一定作用。

Objective： To analyze the expression of visfatin in elderly drome patients, and to explore the relationship of serum lignans and the coronary in elderly patients. Methods： A total of 78 patients with acute patients with acute coronary synseverity of coronary heart disease coronary syndrome patients were ST-segment elevation） according to the type of acute coronary syndrome. Results. Group B （non-ST-seg- ment elevation group） showed higher serum visfatin levels than group A （ST-segment elevation group）, serum visfatin levels of both group A and group B were higher than that in group C, visfatin was positively correlated with coronary artery lesion count the Gensini integral （r=0. 496, 0. 752,P〈0.01）. Conclusion： Among elderly patients with acute coronary syndrome, serum visfatin levels reflecte the initial count and the severity of coronary artery disease; the serum visfatin may function in the occurrence and progress of coronary syndrome in elderly patients.