尿微量清蛋白检测在糖尿病肾病的早期诊断中的应用价值

Value of urine microalbumin detection value in the early diagnosis of diabetic nephropathy

目的:探讨尿微量清蛋白(mAlb)检测在糖尿病肾病的早期诊断中的应用价值。方法:选择我院2008年1月～2012年1月确诊的100例糖尿病患者,包括60例糖尿病肾病患者(DN组)和40例糖尿病早期患者(早期DM组),另选30例体检健康者为对照组。采集所有研究对象的静脉血以及尿液,检测血糖、血肌酐、尿素氮及尿微量清蛋白。结果:对照组空腹血糖(FBG)为(5.12±0.45)mmol/L,尿素氮(BUN)、血肌酐(Scr)、mAlb定量异常均为0例,mAlb为(8.5±1.2)mg/L;早期DM组FBG为(7.65±1.32)mmol/L、BUN、Scr、mAlb定量异常分别为9(30.0%)、8(20.0%)、33(82.%)例,mAlb为(25.3±9.8)mg/L,DN组FBG为(8.56±2.54)mg/L、BUN、Scr、mAlb定量异常分别为50(83.3%)、55(91.7%)、60(100.0%)例,mAlb为(55.1±22.5)mg/L。早期DM组及DN组与对照组比较,差异有统计学意义(P<0.05);DN组BUN、Scr、mAlb定量异常率及mAlb与早期DM组比较,差异有统计学意义(P<0.05);早期DM组及DN组中,mAlb定量异常率显著高于BUN、Scr异常率,差异有统计学意义(P<0.05)。结论:mAlb有助于糖尿病肾病的早期诊断。

Objective. To investigate the value of urinary microalbumin （mAlb） detection in the early diagnosis of diabetic nephropathy. Methods. A total of 100 diabetes cases that were diagnosed during January 2008 and January 2012 were selected, including 60 cases of patients with diabetic nephropathy （DN group） and 40 cases of patients with early diabetes （early DM group）, another 30 healthy counterparts were also selected as control group. Venous blood and urine were collected from these subjects for detecting blood glucose, serum creatinine, blood urea nitrogen and urinary microalbumin. Results. In the control group, FBG was （5.12±0.45） mmol/L, quantitative detection of BUN, Scr, mAlb were all normal, mAlb was （8.5±1.2） mg / L. In early DM group, FBG was （7. 65±1.32） mmol / L, 9 （30.0%）,8 （20.0M）, and 33 cases （82%） showed abnormal BUN,Ser,mAlb, respectively; mAlb was （25.3±9.8） mg/L. IntheDN group, FBG was （8. 56±2. 54） mg / L, 50 （83. 3%）, 55 （91.7%）, and 60 eases （100.0%）showed abnormal BUN, Scr, mAlb, respectively; mAlb was （55.1±22.5） mg/L. Significant differences were observed when these data of early DM group and DN group were compared with that of the control group. There were significant difference in abnormality rate of BUN,Ser,mAlb and in mAlb. In both DM group and DN group, abnormality rate of mAlb was significant higher than the abnormality rate of BUN,Scr,mAlb （P all d0. 05）. Conclusions： mAlb is valuable in early diagnosis of diabetic nephropathy.