新生儿呼吸窘迫综合征应用无创呼吸机的疗效研究

Efficacy of noninvasive ventilator on neonatal respiratory distress syndrome

目的:观察探讨新生儿呼吸窘迫综合征治疗中应用呼吸机无创辅助通气设备的临床效果。方法:将我院收治的44例患有新生儿呼吸窘迫综合征的早产儿随机分为观察组和对照组。观察组采用采用经鼻持续正压通气(NCPAP)联合肺表面活性物质固尔舒治疗。对照组采用常规机械通气(CMV)联合肺表面活性物质固尔舒治疗。观察比较两组患儿治疗前后的动脉血气分析指标、用机时间、氧疗时间、住院时间、临床疗效以及并发症发生情况。结果:观察组患儿氧疗时间以及住院时间均显著低于对照组患儿(P<0.05);两组患儿治疗后动脉血气分析指标无统计学差异(P>0.05),但观察组患儿并发症发生率显著低于对照组(P<0.05)。结论:呼吸机无创辅助通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征并发症少,且患儿氧疗时间和住院时间明显缩短,值得在临床上推广。

Objective：To observe and explore the clinical efficacy of noninvasive ventilator on neo- natal respiratory distress syndrome. Methods. A total of 44 premature infants with neonatal respiratory distress syndrome in our hospital were randomly divided into the observation group and the control group. The observation group was treated with nasal continuous positive airway pressure （NCPAP） joint with pulmonary surfactant solid Ershu treatment. The control group was treated with conventional mechanical ventilation （CMV） joint with pulmonary surfactant solid Ershu treatment. The arterial blood gas analysis indicators, machine time, oxygen therapy, hospitalization time, clinical efficacy, and complications before and after treatment were observed and compared. Results： The oxygen therapy and hospitalization time of the observation group were significantly lower than the control group （P〈0.05; there was no significant difference in arterial blood gas analysis （P;0.05） after the treatment, but the complication rate in the observation group was significantly lower than the control grbup （P〈0.05）. Conclusions. Noninvasive ventilator combined with pulmonary surfactant has little side effect and complication in the treatment of neonatal respiratory distress syndrome, and can reduce the time of oxygen therapy and hospital stay. It is worthy of clinical practice,