哈尔滨医科大学附属第四医院细菌监测及分析

Bacteira monitoring and analysis of Fourth Affiliated Hospital of Harbin Medical University

目的调查我院耐药细菌变迁趋势。方法收集各类标本分离的6202菌株,按照CLSI(2010版)判断标准。结果与2010年相比,2011年球菌比例明显增高到19.41%(P<0.005),粪肠球菌明显降低至9.28%(P<0.025),MSCON明显降低至4.4%(P<0.05),球菌前三位无变化,分别为MRSCON、MRSA、MSSA;2011年杆菌比例明显降低至80.59%(P<0.005),不动杆菌显著增加到21.66%(P<0.005),杆菌前三名分别为不动杆菌、ESBLs(-)及ESBLs(+)肺炎克雷伯杆菌,真菌前三位无变化,分别是白色假丝酵母菌、光滑假丝酵母菌及曲霉菌。结论细菌监测对临床合理应用抗生素及预防细菌耐药有重要的参考价值。

Objective To investigate the trend of drug-resistance bacterial in hospital. Methods 6202 strains of bacteria were i- solated from various types of patients. Antimicrobial susceptibility tests were performed by Kirby Bauer methods and the results were ana- lyzed according to the standards recommended by CLSI （2010 edition）. Results Compared with 2010, coeco bacteria increased to 19.41% （ P 〈 0. 005 ） , cnterococcus faecalis decreased to 9. 28% （ P 〈 0. 025 ） , and MSCON decreased to 4.4% in 2011 （ P 〈 0. 05 ）. The top three of cocco bacteria, which didn＇t change compared with last year. Bacilus decreased to 80. 59% , but acinetobacter increased to 21.66% in 2011 （P〈0. 005）. The top three of bacilus were acinetobaeter, ESBLs （ - ） , k｜ebsielia pneumoniae and ESBLs （ ＋ ） klebsiella pneumoniae. The top three of fungus didn＇t change, which were eandida albicans, smooth false candida and aspergillus. Con- clusion The monitoring and management of antibiotics use should be strengthened further in hospital, which has important value for the monitoring and analysis of bacterial and rational antibiotic application.