COPD患者血清甲状腺激素动态检测临床分析

Clinical analysis of dynamic monitoring serum thyroxines in COPD patients

目的探讨COPD患者甲状腺激素变化的临床意义。方法选择220例COPD患者作为研究对象,入院空腹测定血清甲状腺激素水平,进行治疗好转时复查甲状腺激素。结果 220例COPD患者其中T3、FT3和/或T4、FT4低于正常患者168例(76.34%),死亡24例,好转196例,死亡组T3、FT3、T4、FT4均低于存活组(P<0.05),TSH无明显差异(P>0.05)。196例好转患者出院时T3、FT3、T4、FT4均高于入院时水平(P<0.05)。结论甲状腺激素异常是COPD伴随症状,检查甲状腺功能,可作为观察COPD患者病情严重程度及预后的一项重要参考指标。

Objective To explore the clinical significance of the c}~anging of serum thyroxines in COPD patients. Methods 220 COPD patients were enrolled as the research objects in this study. They were detected of the serum thyroxines on an empty stomach when admitted into the hospital, and redetected after the treatments acted. Results In all the 220 COPD patients, 168 of them have a serum thyroid hormones level below the standard （76. 34% ）. 24 patients ended up in death and 196 were relieved and survived. In the mortality group, the thyroxines including 33, T4, F33 and FT4, were all lower than that of the surviving group （ P 〈 0. 05 ）, while TSH showed no statistical difference （ P 〉0.05 ）. And q3, T4, ~33 and FT4 were all elevated in the surviving goup after the disease was relieved （ P 〈 0. 05）. Conclusion The abnormal level of serum thyroxines is an accompany symptom of COPD. Thyroid hormones may be important mo- nitoring indexes in evaluating the severity and predicting outcome in COPD patients.