吸入性布地奈德、丙酸氟替卡松治疗COPD的临床疗效观察

Observation of clinical effect of glucocorticoid budesonide and fluticasone propionate inhalation in the treatment of COPD patients

目的观察布地奈德、丙酸氟替卡松雾化吸入治疗COPD的临床疗效。方法将210例COPD患者随机分为:A组68例,B组72例和对照组70例,3组均采用综合治疗。A组沙丁胺醇加用布地奈德雾化吸入治疗;B组沙丁胺醇加用丙酸氟替卡松雾化吸入治疗。观察测定3组患者的临床疗效及住院天数等,随访停药1a为喘息性疾病患病人数及患病率。结果 A、B组住院天数、喘憋持续时间、咳嗽持续时间、哮鸣音持续时间方面明显短于对照组,B组明显优于A组,差异均有统计学意义;B组总有效率100.0%,明显高于对照组94.3%;B组喘息性疾病的发病率9.7%,明显低于对照组34.3%和A组25.0%,差异有统计学意义(P<0.05)。结论糖皮质激素布地奈德、丙酸氟替卡松联合沙丁胺醇雾化吸入治疗COPD具有较好的临床疗效。

Objective To observe the clinical effect of the inhalation of glucocorticoid budesonide and fluticasone propionate in the treatment of COPD patients. Methods 210 patients with COPD were randomly divided into the group A （68 cases）, the group B （72 cases） and the control group （70 cases）. All patients were given the conventional treatment. The group A was treated with the aerosol in- halation of pulmicort, and the group B was treated with the aerosol inhalation of pulmicort and fluticasone propionate additionally. The clinical therapeutic effects, duration of hospital stays and tidal breathing lung function were observed among the three groups, and the number and incidence of patients with gasping illness were followed up 1 year after discontinuation. Results The improvement of duration of hospital stay, asthmatic duration, duration of cough, and wheeze duration was more pronounced in the group B than in the group A, and the improvement of the two groups was more pronounced than that of the control group with statistical significance. Conclusion The inha- lation of glucocorticoid budesonide and fluticasone propionate combined with salbutamol has a favorable curative effect in the treatment of COPD patients, which can obviously reduce the prevalence of asthmatic disease.