阿奇霉素治疗支气管哮喘及对外周血T淋巴细胞功能的影响

Observation of clinical efficacy of azithromycin in the treatment of patients with bronchial asthma and its impact on peripheral blood helper T lymphocyte function

目的探讨阿奇霉素治疗支气管哮喘的临床疗效及其对外周血辅助性T淋巴细胞功能的影响。方法 80例支气管哮喘患者随机分为观察组和对照组。对照组给予青霉素静注联合布地奈德、沙丁胺醇雾化吸入治疗,观察组给予阿奇霉素静注联合布地奈德、沙丁胺醇雾化吸入治疗,评价临床疗效。结果观察组总有效率显著高于对照组,P<0.01。治疗后,观察组IFN-γ、IL-4水平与治疗前及对照组比较有显著性差异(P<0.01)。结论阿奇霉素治疗支气管哮喘疗效确切,安全可靠。

Objective To investigate the clinical efficacy of azithromycin in the treatment of patients with bronchial asthma and its impact on peripheral blood helper T lymphocyte function. Methods 80 patients with bronchial asthma were randomly divided into the observation group and the control group. The control group was treated with intravenous injection of penicillin and aerosol inhalation of budesonide and ventolin, and the observation group was treated with intravenous injection of azithromycin and aerosol inhalation of budes- onide and ventolin. The clinical efficacy was evaluated between the two groups. Results The total efficiency was significantly higher in the observation group than in the control group （P 〈 0.01 ）. After the treatment, the levels of IFN-γ and IL-4 levels in the observation group showed a significant difference while compared with itself before the treatment and the control group （ P 〈 0.01 ）. Conclusion Az- ithromycin is a safe and effective method in the treatment of patients with bronchial asthma.