无创正压通气间断雾化吸入在重症哮喘患者中的应用

Application of noninvasive positive pressure ventilation combined with intermittent atomization inhalation in the treatment of patients with severe asthma

目的对无创正压通气并经管道雾化吸入治疗重症哮喘的临床疗效进行研究。方法以95例住院治疗的重症哮喘患者为研究对象,随机分为研究组48例和对照组47例,研究组在常规治疗的基础上给予经鼻(面)罩无创正压通气并雾化吸入治疗,对照组给予单纯常规治疗,比较治疗后两组患者的临床疗效及治疗前后的血气情况。结果研究组总有效率为91.66%,明显高于对照组,两组相比差异有统计学意义(P<0.05),两组患者治疗前PH值、PaO2、PaCO2、SaO2及治疗后SaO2相比差异无统计学意义(P>0.05),而治疗后研究组PH值、PaO2及PaCO2得到了明显改善,两组相比差异有统计学意义(P<0.05)。结论无创正压通气并经管道雾化吸入治疗重症哮喘,提高了患者治疗的有效率,降低了并发症的发生率,值得临床推广应用。

Objective To study the clinical efficacy of noninvasive positive pressure ventilation combined with pipeline atomiza- tion inhalation in the treatment of patients with severe asthma. Methods 95 hospitalized patients with severe asthma were randomly divid- ed into the study group with 47 cases and the control group with 48 cases. All patients were given the conventional treatment, and the stud- y group was treated with nasal （facial） mask noninvasive positive pressure ventilation and atomization inhalation. The curative effect and blood gas were analyzed before and after the treatment between the two groups. Results The total effective rate was 91.66% in the study group, which was significantly higher than that in the control group with statistical significance （ P 〈 0.05 ）. There was no obvious differ- ence of PH value, the levels of PaO2 and PaCO2 between the two groups before the treatment （ P 〉 0.05 ）. PH value and the levels of PaO2 and PaCO2 were better improved with statistical significance （ P 〈 0. 05 ）. Conclusion Noninvasive positive pressure ventilation combined with pipeline atomization inhalation can improve the efficiency of treatment and reduce the incidence of complications in the treatment of patients with severe asthma, which is worthy of clinical application.