LKB1和VEGFR_2评价肺腺癌预后的意义

Prognostic significance of LKB1 and VEGFR_2 in patients with lung adenocarcinoma

目的探讨LKB1、VEGFR2在肺腺癌中的表达情况,分析其预后意义。方法应用免疫组化方法检测46例肺腺癌中LKB1、VEGFR2的表达情况。结果 LKB1在癌旁正常肺组织、淋巴结转移阴性组肺腺癌、Ⅰ～Ⅱ期肺腺癌中的表达阳性率明显高于肺腺癌组织、淋巴结转移阳性组肺腺癌和ⅢA期肺腺癌(82.61%vs 63.04%、75.00%vs 44.44%、75.00%vs35.71%),差异有统计学意义(P<0.05)。VEGFR2在癌旁正常肺组织、淋巴结转移阴性组肺腺癌、Ⅰ～Ⅱ期肺腺癌中的表达阳性率则明显低于肺腺癌组织、淋巴结转移阳性组肺腺癌和ⅢA期肺腺癌(34.78%vs 58.70%、46.43%vs 77.78%、46.88%vs85.71%),差异有统计学意义(P<0.05)。结论 LKB1、VEGFR2在肺腺癌中的表达情况可能与肺腺癌患者的预后有关,LKB1低表达、VEGFR2高表达可能提示预后不良。

Objective To investigate the expression of LKB1 and VEGFR2 in patients with lung adenoearcinoma and its prognos- tic significance. Methods The expression of LKB1 and VEGFR2 in 46 patients with lung adenocarcinoma were detected by immunohisto- chemical staining. Results The positive rate of LKB1 protein in adjacent normal lung tissue, lymph node negative metastasis lung adeno- carcinoma and stage Ⅰ-Ⅱ lung adenocarcinoma were significantly higher than that in tumor lung tissue, positive lymph node metastasis lung adeaocareinoma and stage ⅢA lung adenocarcinoma （82.61% vs 63.04% , 75.00% vs 44.44% and 75.00% vs 35.71% respec- tively, P 〈0. 05 ）. The expression of VEGFR2 in adjacent normal lung tissue, lymph node negative metastasis lung adenocarcinoma and stage Ⅰ-Ⅱ lung adenocarcinoma were significantly lower than that in tumor lung tissue, positive lymph node metastasis lung adenocarci- noma and stage mA lung adenocarcinoma （ 34. 78% vs 58.70% , 46. 43% vs 77.78% and 46. 88% vs 85.71% respeetively, P 〈 0.05 ）. Conclusion The expression of LKB1 and VEGFR2 may be related to the prognosis of patients with lung adenocarcinoma. Low expression of LKBI and high expression of VEGFR2 may reflect the poor prognosis of patients with lung adenocarcinoma.