解脲脲原体感染与早产儿肺损伤的关系

Study of the Relationship between Ureaplasma Urealyticum Infection and Pulmonary Injury of Premature Infants

目的:探讨解脲脲原体(UU)感染与早产儿肺损伤的关系。方法:采集2011年1月至2012年10月深圳市宝安区妇幼保健院新生儿科收治的早产儿的胃液,行UU核酸定量检测,将其中69例阳性患儿作为阳性组,另选70例阴性患儿作为阴性组,比较两组患儿胎膜早破和支气管肺发育不良(BPD)发生率、胸片恢复正常所需时间及血气异常、氧疗、机械通气比例。结果:阳性组胎膜早破发生率为53.6%,胸片恢复正常时间(11.0±7.6)d,血气异常、氧疗、机械通气比例分别为46.4%、60.9%、31.9%;阴性组胎膜早破发生率为45.7%,胸片恢复正常时间(5.5±4.9)d,血气异常、氧疗、机械通气比例分别为28.6%、35.7%、11.4%,两组比较差异均有统计学意义(P<0.05);阳性组BPD发生率为4.3%,阴性组为1.4%,两组比较差异无统计学意义(P>0.05)。结论:定量检测胃液UU核酸对诊治UU感染具有指导意义,且UU感染与早产儿急(慢)性肺损伤密切相关。

Objective： To explore the relationship between ureaplasma urealyticum infection and pulmonary injury of premature infants. Methods： The gastric juice samples of premature infants treated in the hospital from January 2011 to October 2012 were collected for ureaplasma urealytieum detection. Sixty-nine premature infants with positive results were defined as the positive group, while 70 premature infants with negative results were selected as the negative group. The incidence of premature rupture of membrane （PROM） and bronchopulmonary dysplasia, the recovery time of chest radiographs, the ratio of blood gas analysis, oxygen therapy and assisted mechanical ventilation in the two groups were compared. Results： In the positive group, the incidence of PROM was 53.6% , the recovery time of chest radiographs were （11.0＋7.6） days, the ratio of blood gas analysis abnormality was 46.4%, the ratio of oxygen therapy was 60.9% , and the ratio of assisted mechanical ventilation was 31.9%. All the indexes above mentioned were significantly higher than those in the control group （P〈0.05）. The incidence of BPD in the positive group was 4.3% , there was no significant difference compared with the controls. Conclusions： Detection of ureaplasma urealyticum in gastric juice for diagnosis and treatment of UU infection is of guiding significance. Ureaplasma urealyticum infection can cause acute and chronic lung injury in premature infants.