药物基因组学在药物研发中的转化与应用

Transformation and application of pharmacogenomics in drug development

药物安全性和有效性是新药开发和临床用药的核心问题,也是药物基因组学研究的主要内容。目前,已阐明影响药物安全性有效性及个体化差异的首要因素是药物相关生物标记。近年来,药物基因组学各机构正式成立,各发达国家也纷纷出台各种规章,对药物研发中药物基因组学的应用进行规定。药物基因组学在上市药物的评价中已获得巨大的成功,并成功指导了数例肿瘤靶向药物从研发到上市的全过程,缩短了药物开发周期、降低了研究成本及毒副反应。

Drug safety and efficacy have become the core issue in drug development and clinical medication,and also the main content of pharmacogenomics.The drug related biomarkers are responsible for drug safety and efficacy,and the difference in drug responses.Recently,several organizations of pharmacogenomics were established.Many rules have been laid down by many developed countries as to the application of pharmacogenomics in drug researches,which reduce the cycle and cost of drug development,the drug toxic and side effects.