腺苷酸活化蛋白激酶在肺部疾病中的作用

Role of AMPK in pulmonary diseases

腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一种广泛参与人体内能量代谢活动的蛋白激酶。新近的研究发现,AMPK可调控多种疾病发生、发展过程中的病理环节。近年来,AMPK与肺部疾病的关系愈发受到人们的重视,目前研究认为AMPK对肺癌、支气管哮喘及肺动脉高压等肺部疾病的治疗具有潜在的作用。该文就AMPK的生物学特性及其对多种肺部疾病的潜在治疗作用进展做一综述。

AMPK is an important protein kinase,which controls/regulates the activity of energy metabolism in human body.Recent study has found that AMPK plays a critical role in the pathophysiological process of a variety of diseases.In recent years,the relationship between AMPK and pulmonary diseases has aroused extensive attention.Studies suggest that AMPK has a potential role in the treatment of pulmonary diseases such as lung cancer,asthma,acute lung injury,pulmonary hypertension and cystic fibrosis.This review summarizes the biological characteristics of AMPK and its potential therapeutic effect on such diseases.