冬病夏治消喘膏穴位贴敷对稳定期慢性阻塞性肺病患者炎症因子的影响

Effect of Xiaochuan Paste Acupointon Application on Inflammatory Cytokines of Chronic Obstructive Pulmonary Disease in Stable Phase: Based on the Method of Winter Disease Treated in the Summer

目的评价冬病夏治消喘膏穴位贴敷疗法对慢性阻塞性肺病(COPD)稳定期患者气道炎症的影响及作用机制。方法将60例稳定期COPD患者随机分为治疗组和对照组各30例,在西医常规治疗的同时,治疗组给予消喘膏穴位贴敷,对照组给予安慰剂贴敷,两组均于夏季三伏天贴治3次,敷贴治疗前及治疗后6个月分别留取诱导痰,观察诱导痰白细胞计数、中性粒细胞比例及上清液中白细胞介素-8(IL-8)、分泌型IgA(sIgA)水平的变化。结果治疗后治疗组中性粒细胞比例较治疗前下降(P<0.05),对照组治疗前后中性粒细胞比例比较差异无统计学意义(P>0.05)。治疗组治疗后诱导痰中IL-8水平较治疗前及对照组治疗后降低(P<0.05)。治疗组治疗后诱导痰sIgA水平较治疗前及对照组治疗后明显升高(P<0.05)。结论冬病夏治消喘膏贴敷疗法治疗稳定期COPD的可能作用机制在于减轻气道局部炎症反应,增强气道黏膜保护的作用。

Objective To evaluate the effect and mechanism of Xiaochuan Paste （acupoint paste for asthma, XCAP） acupoint application on airway inflammation of chronic obstructive pulmonary disease （COPD） in stable phase. Methods Sixty COPD patients in stable phase were randomized into treatment group and control group with 30 cases in each group. Both groups were given basic treatment. Then the treatment group and control group was given sticking therapy of XCAP and placebo respectively for 3 times in Sanfu （dog days）. The white blood cell, neutrophil, interleukin-8 （IL-8） and secretory IgA （sIgA） in induced sputum were detected before and after 6-month treatment. Results Comparing with before treatment and the control group, the neutrophil ratio and IL-8 content was significantly decreased in the treatment group after treatment （P〈 0.05）. Comparing with before treatment and the control group, the sIgA content was significantly increased in the treatment group after treatment （P〈0. 05）. Conclusion The action mechanism of XCAP may be reducing the local inflammatory response of airway and enhancing the protection of airway mucosa.