癫痫患者P50听觉诱发电位的研究

Study on P50 autditory evoked potentials in the patients with epilepsy.

目的 探讨 P5 0在癫痫患者检测中的临床价值。方法 对 2 5例癫痫患者 (其中 7例额叶癫痫 ;18例颞叶癫痫 )进行 P5 0测试 ,分析 P5 0波的潜伏期和波幅 (峰峰值 )以及在不同刺激频率时 P5 0波幅 (峰峰值 )的比率。选择年龄、性别与患者组相匹配的 2 5名健康受试者对照组。结果 癫痫患者组 P5 0波的潜伏期较长 ,波幅则显著减低 ,其中以 18例颞叶癫痫患者表现显著 ,7例额叶癫痫患者不明显。刺激频率稍加快时 ,患者组 P5 0的波幅比率明显减小。结论 P5 0波的潜伏期和波幅反应异常与颞叶功能障碍密切相关 ,可帮助临床鉴别额、颞叶癫痫灶 ;其波幅衰减现象似与癫痫发作间期行为和认知改变相关 ,但也可能受药物的影响。

Objective To evaluate the clinical value of P50 auditory evoked potentials(AEP) in patients with epilepsy.Methods P50 evoked potentials in the patients with complex partial seizures of frontal((n=7) and temporal(n=18) lobe origin were recorded.The latency and amplitude of P50 AEP and the ration of the amplitudes at difference frequency were analyzed in 25 patients and 25 controls.Results P50 was significantly reduced in amplitude and prolonged in latency in temporal lobe seizure patients as compared with that in control group.Conclusion P50 AEP might be affected by temporal lobe dysfunction and could be used for differentiating frontal and temporal seizure foci.P50 attenuation differences may be related to interictal behavioral or cognitive changes.