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SIRT1与肿瘤耐药的研究进展

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摘要 肿瘤一直是威胁人类健康和生存的最严重的疾病之一。随着诊疗设备及技术的日益完善,肿瘤患者在生存时间及生存质量上有了很大提高。但近50年间恶性肿瘤的死亡率并没有明显的下降。目前治疗肿瘤的主要手段有手术、化疗、放疗、免疫治疗等。在我国,约70—80%的肿瘤患者在确诊时已为中、晚期,失去了手术机会。因此,化学药物治疗成为中、晚期患者治疗的主要手段。然而,肿瘤耐药性的产生是临床治疗各种肿瘤面临的一个主要障碍,成为肿瘤治疗的瓶颈。
出处 《滨州医学院学报》 2013年第2期142-145,共4页 Journal of Binzhou Medical University
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  • 1Broxterman HJ, Gotink K J, Verheul HM. Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib [ J ]. Drug Resist Updat,2009,12 (4,5) : 114-126.
  • 2Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity [ J ]. Nat Rev Mol Cell Biol, 2005,6 ( 3 ) : 298-305.
  • 3Saunders LR,Verdin E. Sirtuins:critical regulators at the crossroads between cancer and aging [ J ]. Oncogene, 2007,26 ( 37 ) : 5489- 5504.
  • 4MottaMC, Divecha N, LemieuxM, et al. Mammalian SIRT1 represses forkhead transcription factors [ J ]. Ce11,2004,116 (6) :551-563.
  • 5Cohen HY, Miller C, Bitterman KJ,et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase [ J]. Sci- ence, 2004, 305 (g) : 390-392.
  • 6Chen WY, Wang DH, Yen RC, et al. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependeut DNA-damage responses [ J]. Cell ,2005,123 (5) :437-448.
  • 7Cha EJ,Noh SJ,Kwon KS,et al. Expression of DBC1 and SIBT1 is associated with poor prognosis of gastric carcinoma [ J ]. Clin Cancer Res ,2009,15 ( 13 ) :4453-4459.
  • 8Jang KY, Hwang SH, Kwon KS, et al. SIRTI expression is associated with poor prognosis of diffuse large B-cell lymphoma[ J]. AmY Surg Pathol,2008,32(10) : 1523-1531.
  • 9Lee H,Kim KR,Nob SJ,et al. Expression of DBCI a" SIRTI is asso- ciated with poor prognosis for breast carcinoma [ J ]. Hum Pathol, 2011,42(2) :204-213.
  • 10Huffman DM. Grizzle WE, Bamman MM ,et aL SIRTI is significant- ly elevated in mouse and human prostate cancer [ J ]. cancer Res, 2007,67(14) :6612-6618.

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