1Orange JS,Salazar-Mather TP,Opal SM,et al.Mechanism of Interleukin 12-Mediated Toxicities during exoerimental viral infection:role of tumor neccosis factor and glucocoriticoids[J].J Exp Med，1995，181：901.
2Gately MK，Gubler U，Brunda MJ,et al.Interleukin 12：a cytokine with therapeutic potential in ancology and infections disease[J]．Therapeutic Immunol,1994，1：187．
3Sarmiento CM,Riely JH，Knaack PA，et al．Biologic effects of recombinant human interleukin 12 in squirrel monkeys[J].Lab Invest,1994，71：862．
4Mehrotra PT,Wu D，Crim,JA．et al.Effects of IL-12 on the generation of cytotocix activity in human CD8+T Lymphocytes[J].J Immunol ，1993，151：2444.
5Milich DR,Wolf SF，Hughes JL，et al.Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis Be antigen transgenic mice[J]．Proc Natl Acad Sei USA．1995，92：6847.
6Maruyama T，Schodel F，Iino S，et al.Distinguishing between acute and symptomatic chronic heptitis B virus infection[J]．Gastroenterology ,1994，106：1006.
7Schmitt E，Hoehn P，Germann T，et al．Differential effects of interleukin-12 on the development of naive mouse CD4+cells[J] .Eur J Immunol ,1994，24：793．
8Cavanaugh VJ，Guidotti LG,Chisari FV,et al.Interleukin-12 inhitis hepatitis B Virus Replication in transgenic mice [J].J Viruology,1997，71(4)：3236．
9Rossol S．Marinos G,Garucci P．et al.Interleukin-12 induction of THI cytolines is important for viral clearance in chronic hepatitis B[J].J Clin Invest,1997，99(12)：3025．
10Vingerhtts J,Michielsen P，Vanham G．et al.HBV-specific lymphoproliferative and cytokine responses in patients with chromic hepatitis B[J].J Hepatology,1998，28：8．
