病毒性肝炎患者IL-8、IL-10水平与肝功能损伤的关系

Relationship between serum IL-8、IL-10levels and liver lesion in patients with Viral hepatitis

采用双抗体夹心ELISA法对76例病毒性肝炎患者的ＩＬ－８、ＩＬ－１０进行了测定。结果：各组肝炎患者ＩＬ－８检测水平显著高于正常对照组（Ｐ＜０．０５），以ＣＨ－Ⅱ－Ⅲ组ＩＬ－８水平最高；ＣＨ－Ⅱ－Ⅲ、LC、SH三组ＩＬ－１０水平显著高于正常对照组和ＣＨ－Ⅰ组，在这三组中又以ＣＨ－Ⅱ－Ⅲ＜ＬＣ＜ＳＨ的顺序递增（Ｐ＜０．０５）。ＩＬ－８与肝炎患者的SB和ALT水平负相关。检测血清ＩＬ－８在判断病毒性肝炎患者肝脏损伤程度上有一定价值，在重型肝炎和肝炎后肝硬化联合检测ＩＬ－８、ＩＬ－１０可以预测其预后。

The serum IL-8、IL-10 levels were determined in 76 patients with viral hepatitis by double-antibody sandwich ELISA.Results showed that the IL-8 levels in patients with any type of hepatits were higher significantly than normal persons;IL-8 levels in patients with chronic moderate and serious degree hepatitis was highest than others Serum IL-10 levels were increased sequentially in patients with chronic(moderate, serious degree)hepatitis、liver cirrhosis、severe hepatitis compared with normal control There was a positive correlation between serum IL-8 levels and SB、ALT. Our results suggested that IL-8 could reflect the degree of liver damage in patients with hepatitis, and Detecting IL-8 and IL-10 could predicting prognosis in patient with severe hepatitis,liver cirrhosis