探讨慢性肝炎患者血清肝纤维化指标的临床价值

Study on clinical value of serum parameters of liver fibrosis in chronic viral hepatitis

探讨慢性肝炎患者血清肝纤维化指标（ＨＡ、ＰＣⅢ、Ⅳ－Ｃ、ＬＮ）的临床实用价值。对２５００例慢性肝炎患者，用放射免疫法进行血清ＨＡ、ＰＣⅢ、Ⅳ－Ｃ、ＬＮ的检测，其中２３７例进行肝穿刺及肝脏病理组织学检查。结果显示２５００例轻、中、重度慢性肝炎患者的ＨＡ、ＰＣⅢ、Ⅳ－Ｃ、ＬＮ指标均有明显差异（Ｐ＜０．０１）；４项肝纤维化指标水平与乙肝患者的肝脏炎症活动度分级、肝纤维化程度分期与病理组织学分度均存在显著相关（ｒ＝０．２５６－０．３９９）。血清肝纤维化指标对判断慢性肝炎的肝纤维化和肝硬化倾向具有临床实用意义。

This paper is determining the clinical value of serum liver fibrosis parameters in chronic viral hepatitis.Serum hyaluronic acid(HA),procollagen III(PCIII),type IV collagen(IV-C)and laminin(LN)were detected in 2500 samples of chronic viral hepatitis by radioimmunoassay;and biopsy and histopathologic examination for liver were operated in 23 patient.The serum parameters of live fibrosis(HA,PCⅢ,Ⅳ-C and LN)showed significant difference(P>0.01)in mild,moderate,severe chronic viral hepatitis,and were significantly correlated with in inflammatory grading,fibrosis scoring,pathological staging in chronic hepatitis B(r=0.256-0.399).The conclusion is that the serum liver fibrosis parameters may be useful judging the prognosis for chronic viral hepatitis.