复律宁颗粒治疗老年室性早搏患者的临床研究

Clinical research of ＂Fulvning Granule＂ on ventricular premature contractions in the elderly

目的观察复律宁颗粒治疗老年室性早搏患者的临床疗效及安全性。方法将60例老年室性早搏患者随机分为两组，治疗组（30例）口服复律宁颗粒，对照组（30例）口服稳心颗粒，疗程均为4W。所有人组患者均于治疗前、治疗后检测24h动态心电图以及安全性参数：血白细胞（WBC）、血红细胞（RBC）、血红蛋白（Hb）、血小板（PLT）、尿白细胞（LEU）、尿红细胞（ERY）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、血肌酐（Scr）、血尿素氮（BUN）。治疗前、治疗中（治疗2W）、治疗后各检测1次心电图，对比所有患者服药前后上述指标的变化。结果治疗后，室性早搏次数总有效率比较，差异无统计学意义（P=0．079）；而中医症候疗效比较，差异有统计学意义（P=0．028）；单项中医症候疗效比较，胸闷胸痛症候疗效比较差异有统计学意义（P=0．028），心悸不宁、气短乏力、头晕心烦中医症候疗效比较差异无统计学意义（P值分别为0．774、0．573、0．787）。两组患者治疗后安全性参数比较，差异无统计学意义（P〉0．05），治疗期间无不良反应发生。结论复律宁颗粒对老年室性早搏患者具有良好的临床疗效，安全性好。

Objective To observe the clinical efficacy and safety of ＂Fulvning Granule＂ on ventricular premature contractions in the elderly. Methods 60 patients were randomized into treatment group in which 30 cases were treated by ＂ Fulvning Granule＂ and control group in which 30 cases were treated by ＂Wenxin Granule＂, with a course of 4 weeks. Before and after treatment, Holter, white blood cell （WBC）, red blood cell （RBC）, hemoglobin （Hb）, blood platelet （PLT）, leukocytes （LEU）, erythrocyte （ERY）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, serum creatinine （Scr）, blood urea nitrogen （BUN） were analyzed. EKG was detected every two weeks. Result After treatment, there was no significant difference on the number of ventricular premature contractions in the elderly （P =0.079 ）. But traditional Chinese medicine symptoms were improved more in treatment group （P=0.028）. TCM syndrome of chest tightness showed statistical significance （P =0.028 ）. Others didn＇t （P=0.774,0.573,0.787）. And it showed no significant difference on safety index after treatment （P〉 0.05 ）. Moreover, no adverse events happened during treatment. Condusion ＂FuNning Granule＂ is quite effective and safety on ventricular premature contractions in the elderly.