转移相关基因CD_(44)V_6表达与乳癌转移和预后关系的研究

Expression of CD_(44)V_6 and Prognosis of Human Breast Cancer

目的 :探讨 CD4 4V6表达与乳癌转移和预后之间的关系。方法 :用免疫组化染色方法和微波抗原修复技术 ,检测 78例原发性乳癌组织中 CD4 4V6蛋白的表达 ,分析各临床病理因素和 CD4 4V6表达与乳癌术后 5年生存率的关系。结果 :CD4 4V6的阳性表达率为 55.1% ( 4 3/ 78) ,腋淋巴结阳性乳癌中的表达率为 72 .7% ( 32 / 4 4 ) ,明显高于阴性乳癌中 CD4 4V6表达率 32 .4 % ( 11/ 34 ) ,P<0 .0 1。CD4 4V6阳性组乳癌患者的预后明显较阴性组差 ( P<0 .0 5)。结论 :CD4 4V6表达与乳癌转移和预后密切相关 ;CD4 4V6、腋淋巴结状况、肿瘤大小、组织学分级和 TNM分期是影响乳癌术后 5年生存率的重要因素。

Objective:To analyze the relationship between expression of CD 44 V 6 protein and prognosis in breast cancer.Methods:Expression of CD 44 V 6 protein in 78 patients with breast cancer was detected by immunohistochmistry and antigenretrieving techniques,the relationship between expression of CD 44 V 6 and clinicopathological factors and prognosis was analyzed.Results:The total expression rate of CD 44 V 6 protein was 55.1%(43/78) in the whole group.The expression rate of CD 44 V 6 of breast cancer with axillary lymph nodes positive group (72.7%,32/44) was much higher than that with axillary lymph nodes negative group (32.4%,11/34)( P <0.01).Prognosis of the patients with positive expression of CD 44 V 6 was poorer than that of the patients with negative expression of CD 44 V 6.Conclusion:Expression of CD 44 V 6 protein was closely related to the prognosis of the patients with breast cancer.Expression of CD 44 V 6,metastasis of axillary lymph nodes,tumor size,histological grade and TNM stage were important factors to influence five year survival rate in breast cancer.