喉癌患者血清可溶性细胞间粘附分子-1水平与肿瘤分期的关系

Serum Levels of Soluble Intercellular Adhesion Molecule-1 in the Patients with Laryngeal Carcinoma:Correlation with Tumor Stages

目的 :为阐明血清可溶性细胞间粘附分子 - 1( s ICAM- 1)水平与喉癌发展和颈淋巴结转移的关系。方法 :采用双抗体夹心酶联免疫测定法 ,测定 4 2例 ～ 期喉癌患者和 4 0例健康对照者血清 s ICAM- 1水平。结果 :喉癌患者血清 s ICAM- 1( 12 2 5.34± 142 .2 2μg/ L )水平明显高于健康对照者 ( 536.98± 36.15μg/ L ) ( P<0 .0 0 1) , ～ 期患者 s ICAM- 1水平高于 ～ 期 ( P<0 .0 5)。伴颈淋巴结转移者与肿瘤局限者无明显差别。结论 :随着病程发展 ,喉癌患者血清 s ICAM- 1水平逐渐升高 ,癌细胞呈现免疫逃逸现象。

Objective:To elucidate the relationship between serum levels of soluble intercellular adhesion molecule 1(sICAM 1) in the patients with laryngeal carcinoma and tumor progression as well as metastasis.Methods:Serum samples from 42 patients with laryngeal carcinoma (stage Ⅰ to Ⅳ) and 40 healthy individuals were tested for sICAM 1 using a sandwich enzyme linked immunosorbent assay technique.Results:Patients with laryngeal carcinoma had significant higher serum levels of sICAM 1 than healthy individuals ( P <0.001).Stage Ⅲ Ⅳ patients demonstrated significantly higher serum levels of sICAM 1 than stage Ⅰ Ⅱ patients ( P <0.05).No difference in serum sICAM 1 levels was observed between patients with localized tumor and those with metastasis.Conclusion:Serum levels of sICAM 1 in the patients with laryngeal carcinoma increase with the tumor progression.