白英的化学成分研究(Ⅱ)

Chemical constituents from Solanum lyratum Thunb.(Ⅱ)

目的对中药白英(Solanum lyratum Thunb.)的化学成分进行研究。方法采用正相硅胶柱色谱、Sephadex LH-20柱色谱及制备薄层等方法进行分离纯化,根据理化性质以及光谱数据,对得到的化合物进行结构鉴定。结果从白英全草60%乙醇提取物的乙酸乙酯萃取部位分离得到12个单体化合物,分别鉴定为N-顺式阿魏酰酪胺(1)、N-反式阿魏酰酪胺(2)、N-反式阿魏酰奥克巴胺(3)、尿苷(4)、尿嘧啶(5)、胸苷(6)、β-吲哚羧基酸(7)、木兰苷6-甲氧基-7-O-β-D-吡喃葡糖香豆素苷(8)、1-O-β-D-葡糖吡喃糖基-(2S,3R,4E,8Z)-2-[(2-羟基十六酰)酪胺]-4,8-十八碳二烯基-1,3-二醇(9)、1-O-β-D-葡糖吡喃糖基-(2S,3R,4E,8E)-2-[(2-羟基十六酰)酪胺]-4,8-十八碳二烯基-1,3-二醇(10)、薯蓣皂苷元(11)、薯蓣皂苷元-3-O-α-L-鼠李吡喃糖基-(1→2)-β-D-葡糖苷酸糖醛酸甲酯(12)。结论化合物4、5、6、7、9为首次从茄属植物中分离得到,化合物8为首次从该种植物中分离得到。

Objective To investigate the chemical constituents of 60% alcohol extract from Solanum lyratum Thunb..Methods The compounds were separated by column chromatography over silica gel and Sephadex LH-20 and preparative TLC.Their structures were elucidated on the basis of physicochemical property and spectral data.Results Twelve compounds were separated and identified as： N-cis-feruloyltyramine（1）,N-trans-feruloyltyramine（2）,N-trans-feruloyloctopamine（3）,uridine（4）,uracil（5）,thymidine（6）,β-indole carboxylic acid（7）,magnolioside（8）,1-O-β-D-glucopyranosyl-（2S,3R,4E,8Z）-2-[（2-hydroxyhexadecanoyl）amido]-4,8-octadecadiene-1,3-diol（9）,1-O-β-D-glucopyranosyl-（2S,3R,4E,8E）-2-[（2-hydroxyhexadecanoyl）amido-]-4,8-octadecadiene-1,3-diol（10）,diosgenin（11）,and diosgenin-3-O-α-L-rhamnopyranosyl-（1→2）-β-D-glucuroniduronic acid methyl ester（12）.Conclusion Compounds 4,5,6,7 and 9 are separated from Solanum for the first time while compound 8 is separated from S.lyratum for the first time.