孕妇血清铜蓝蛋白氧化酶活力的变化

Change of serum ceruloplasmin oxidase activity in pregnancy

目的 :探讨孕妇血清铜蓝蛋白氧化酶活力的变化。方法 :以O Dianisidin为基质 ,采用联大茴香胺酶比色法测定87名孕妇和 6 5名健康非妊娠妇女血清铜蓝蛋白 (sCP)的活力。结果 :妊娠小于 8周的妇女与健康非妊娠妇女的sCP活力水平差异无显著性 (P >0 .0 5 )。妊娠大于 8周的妇女sCP活力均高于健康非妊娠妇女 (P <0 .0 1) ,而晚期妊娠妇女sCP活力均高于其他各组 (P <0 .0 1)。结论 :妇女妊娠 8周后sCP升高是其对妊娠期铜、铁代谢改变的一种适应 ;对一些临床疾病的鉴别诊断有参考价值。

Objective:To study the change of serum ceruloplasmin oxidase(sCP) activity in pregnant women.Methods:The sCP activity of 87 pregnant women and 65 healthy nonpregnant women was determined with O Dianisidin as substrate.Results:The difference in sCP activity between the normal women and pregnant women for less than 8 weeks was not significant( P >0.05).The sCP activity in pregnant women for more than 8 weeks increased significantly,in comparison with normal women( P <0.01).However,the sCP activity in the late stage of pregnancy was higher than that of other groups( P <0.01).Conclusions:The increase in sCP after 8 weeks of pregnancy is due to the adaptation to the change of copper and iron metabolism;Therefore it is useful in differential diagnosis. [