膀胱癌组织p53表达的临床意义

The clinical significance of p53 expression in transitional cell bladder carcinoma

目的 :探讨膀胱癌组织 p5 3表达的预后价值。 方法 :采用免疫组化方法 ,研究 5 6例膀胱癌组织及 10例正常对照粘膜组织中 p5 3的表达。结果 :膀胱癌组织 p5 3表达阳性率为 5 1.79% (2 9/ 5 6 ) ,而正常对照粘膜中均无表达 ;p5 3阳性率与病理分级、临床分期有关 ,Ⅰ级 2 0 .0 0 % ,Ⅱ级 45 .45 % ,Ⅲ级 70 .83% (P <0 .0 5 ) ;T1期 15 .79% ,T2 期 5 5 .0 0 % ,T3 期 88.2 4% (P <0 .0 0 5 )。p5 3阳性率及水平在低分化及侵袭性肿瘤中显著增高 ;p5 3阳性肿瘤患者比阴性患者肿瘤的复发率及病死率明显增高 (P <0 .0 1和P <0 .0 5 )。结论 :p5 3过度表达可作为膀胱移行细胞癌预后评估的指标之一。

Objective:To investigate the prognostic value of p53 expression in bladder carcinoma.Methods:P53 was detected by immunohistochemical method in 56 specimens of transitional cell bladder carcinoma and 10 normal bladder mucosa as controls.Results:p53 was positive in 29 of the 56(51.79%),while it was negative in all the 10 controls.The p53 positive rate in grade Ⅰ,Ⅱ,and Ⅲ tumors was 20.00%,45.45%,and 70.83% respectively( P <0.05),and in stage T\-1,T\-2,and T\-3 tumors was 15.79%,55.00% and 88.24% respectively( P <0.005).The p53 positive rate and level was higher in invasive bladder carcinoma.The recurrence and fatality rates were higher in positive cases than those in negative cases( P <0.01 and P <0.05).Conclusions:The immunohistochemical p53 expression could be used as one of the important prognostic indicators in transitional cell bladder carcinoma. [