青年妇女早期子宫颈癌的临床及病理特点

Analysis of clinical and pathological characteristics of early stage cervical cancer in young women

目的 :分析 <40岁妇女子宫颈癌在临床及病理方面的特点。方法 :以 <40岁早期子宫颈癌 89例为研究组 ,选择同期手术 ,>40岁早期子宫颈癌 89例作为对照组 ,用SPSS分析软件对两组临床及病理学资料进行对照分析。结果 :<40岁患者中 ,发现不规则阴道流血或白带增多在 1个月内就诊者 85 .4% ,多于对照组 5 2 .9% (P <0 .0 0 5 ) ;其临床Ⅰa期患者高于对照组 (P <0 .0 5 ) ,肿瘤最大直径≥ 4cm者占 5 5 .1% ,高于对照组 39.3% (P <0 .0 5 ) ;病理类型腺癌占 18.0 % ,高于鳞癌 4.5 % (P<0 .0 0 5 )。肿瘤呈菜花型占 6 2 .9% ,高于对照组的 42 .7% (P <0 .0 0 5 ) ;两组的组织学分级及盆腔淋巴结转移率相似。 <40岁者预后差 ,其 5年生存率为 78.7%。结论 :<40岁的早期子宫颈癌预后差 ,对有不良预后因素者治疗应选用手术与放射联合治疗 ,必要时辅以化疗。

Objective:To investigate the clinical and pathological characteristics of stage Ⅰ and Ⅱ cervical cancer in women under 40. Methods:Eighty nine young women with stage Ⅰ and Ⅱ cervical cancer treated in our hospital were studied and 89 older women with cervical cancer treated during the same period served as contorl,SPSS softwore was used to analyse the clinical and pathological data of the two groups.Results:Irregular vaginal bleeding and leukorrhea increasing occurred more frequently in the study group(<40 years old) than those in the control group(85.4% vs 52.9%, P <0.005),and the diagnosis rate of stage Ⅰ was higher.There were more tumors larger than 4 cm in diameter(55.1% vs 39.3%, P <0.05),and the morphological type of cauliflower occured more frequently(62.9% vs 42.7%, P <0.005).The histological grade and pelvic lymph nodes metastasis rate were similar in the two groups.The prognosis of young patients was poor;5 year survival rate was 78.7%.Conclusions:The prognosis of early stage cervical cancer in patients under 40 was poor.Surgery combined with radiotherapy should be used for the patients with bad prognostic factors,chemotherapy can be added when necessary. [