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听神经瘤药物靶向治疗 被引量:4

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摘要 听神经瘤是一种良性肿瘤,通过有效的药物靶向性治疗听神经瘤,除了能控制肿瘤生长获得良好的治疗效果外,还能避免手术带来的面神经损伤等不良预后。本文就听神经瘤发展的生物学机制以及药物靶向治疗进展进行综述,以期探讨可能的药物干预靶点,并为后续科学研究和临床试验提供依据。
出处 《国际耳鼻咽喉头颈外科杂志》 2013年第3期143-145,共3页 International Journal of Otolaryngology-Head and Neck Surgery
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  • 1Wang Z,Lu Y,Tang J,et al.The phosphorylation status ofmerlin in sporadic vestibular Schwannomas.Mol Cell Biochem,2009,324(1-2):201-206.
  • 2Yang C,Asthagiri AR,Iyer RR,et al.Missense mutations inthe NF2 gene result in the quantitative loss of merlin protein andminimally affect protein intrinsic function.Proc Natl Acad Sci U SA,2011,108(12):4980-4985.
  • 3Lallemand D,Curto MS,Saotome I,et al.NF2 deficiencypromotes tumorigenesis and metastasis by destabilizing adherensjunctions.Genes Dev,2003,17(9):1090-1100.
  • 4Ammoun S,Flaiz C,Ristic N,et al.Dissecting and targetingthe growth factor-dependent and growth factor-independentextracellular signal-regulated kinase pathway in humanschwannoma.Cancer Res,2008,68(13):5236-5245.
  • 5James MF,Han S,Polizzano C,et al.NF2/Merlin is a novelnegative regulator of mTOR complex 1 and activation of mTORClis associated with meningioma and schwannoma growth.Mol CellBio,2009,29(15):4250-4261.
  • 6Kaempchen K,Mielk K,Utermark T,et al.Upregulation of theRacl/JNK signaling pathway in primary human schwannoma cells.Hum Mol Genet,2003,12(11):1211-1221.
  • 7Femandez-Valle C,Tang Y,Ricard J,et al.Paxillin bindsschwannomin and regulates its density-dependent localization andeffect on cell morphology.Nat Genet,2002,31(4):354-362.
  • 8Zhou L,Ercolano E,Ammoun S,et al.Merlin-deficienthuman tumors show loss of contact inhibition and activation ofWnt/p-catenin signaling linked to the PDGFR/Src and Rac/PAKpathways.Neoplasia,2011,13(12):1101-1112.
  • 9Morrison H,Sherman LS,Legg J,et al.The NF2 tumorsuppressor gene product,merlin,mediates contact inhibition ofgrowth through interactions with CD44.Genes Dev,2001,15(8): 968-980.
  • 10Li W,You L,Cooper J,et al.Merlin/NF2 suppressestumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.Cell,2010,140(4):477-490.

同被引文献27

  • 1曹学成.大鼠坐骨神经的解剖学研究[J].中国实验动物学杂志,2002,12(4):213-214. 被引量:19
  • 2Blakeley JO, Evans DG, Adler J, et al. Consensusrecommendations for current treatments and accelerating clinicaltrials for patients with neurofibromatosis type 2 [ J]. Am J MedGenet A,2012, 158A ( 1 ): 2441. DOI: 10. 1002/ajmg.a. 34359.
  • 3Blakeley J. Development of drug treatments for neurofibromatosistype 2-associated vestibular schwannoma [ J ]. Curr OpinOtolaryngol Head Neck Surg, 2012,20(5) :372-379. DOI: 10.1097/MOO. 0b013e328357d2ee.
  • 4Maniakas A, Saliba I. Neurofibromatosis type 2 vestibularschwannoma treatment : a review of the literature, trends, andoutcomes[ J]. Otol Neurotol, 2014,35(5) :889-894. DOI: 10.1097/MAO. 0000000000000272.
  • 5Gehlhausen JR, Park SJ, Hickox AE, et al. A murine model ofneurofibromatosis type 2 that accurately phenocopies humanschwannoma formation[ J]. Hum Mol Genet,2015 ,24( 1) : 1-8.DOI: 10.1093/hmddu414.
  • 6Giovannini M,Robanus-Maandag E, van der Valk M,et al.Conditional biallelic Nf2 mutation in the mouse promotesmanifestations of human neurofibromatosis type 2 [ J ]. GenesDev, 2000,14(13) :1617-1630.
  • 7Giovannini M,Robanus-Maandag E, Niwa-Kawakita M, et al.Schwann cell hyperplasia and tumors in transgenic miceexpressing a naturally occurring mutant NF2 protein [ J ]. GenesDev, 1999,13(8) :978-986.
  • 8Neff BA,Voss SG, Allen C, et al. Bioluminescent imaging ofintracranial vestibular schwannoma xenografts in NOD/SCID mice[J]. Otol Neurotol, 2009, 30 ( 1 ) : 105-111. DOI: 10.1097/MAO.ObOI3e31818b6cea.
  • 9Tanaka K, Eskin A, Chareyre F, et al. Therapeutic potential ofHSP90 inhibition for neurofibromatosis type 2 [ J ]. Clin CancerRes, 2013,19 ( 14) :3856-3870. DOI: 10. 1158/1078-0432.CCR-12-3167.
  • 10Wong HK, Lahdenranta J, Kamoun WS, et al. Anti-vascularendothelial growth factor therapies as a novel therapeutic approachto treating neurofibromatosis-related tumors [ J ]. Cancer Res,2010,70 (9):3483-3493. DOI: 10. 1158/0008-5472. CAN-09-3107.

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