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卡马西平对癫痫患者颈总动脉内中膜厚度的影响及相关危险因素研究 被引量:4

Effects of Carbamazepine on Carotid Artery Intima Media Thickness in Epileptic Patients and Relative Risk Factors
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摘要 目的:观察卡马西平(CBZ)对癫痫患者颈总动脉内中膜厚度的影响,并探讨其相关危险因素。方法:选取我院就诊的40例单一服用CBZ治疗时间大于1年的癫痫患者作为试验组,另选取40名健康志愿者作为对照组。分别测量受试者左、右两侧颈总动脉内中膜厚度(CA-IMT),计算平均CA-IMT(左、右两侧CA-IMT平均值),并检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及同型半胱氨酸(Hcy)等。对影响CA-IMT的相关危险因素(年龄、性别、体质量指数、病程、服药时间等)进行多元回归分析。结果:试验组双侧CA-IMT及平均CA-IMT均较对照组显著增加(P<0.001);试验组TC、TG、LDL-C、Hcy水平均较对照组显著升高(P<0.05)。多元回归分析结果显示,平均CA-IMT与服药时间呈正相关(P<0.05),即服药时间越长,患者平均CA-IMT越高。结论:服用CBZ的癫痫患者CA-IMT增加与服药时间有关,故长期服用CBZ的患者有必要定期检测血脂及Hcy。 OBJECTIVE:To observe the effects of carbamazepine(CBZ) on carotid artery intima media thickness(CA-IMT) in epileptic patients and its relative risk factors.METHODS:40 epileptic patients receiving CBZ alone more than 1 year were collected from our hospital as trial group,and other 40 healthy volunteers as control group.CA-IMT at both sides of common carotid artery were measured,and average CA-IMT(average value of CA-IMT at both sides of common carotid artery) was calculated.Blood lipid(TC,TG,LDL-C and HDL-C) and Hcy level were detected.Multivariable regression analysis were adopted to select the relative risk factors(age,gender,BMI,course of disease,duration of therapy,etc.) of CA-IMT.RESULTS:The CA-IMT of both sides and average CA-IMT were significantly increased in trial group,compared with control group(P0.001).TC,TG,LDL-C and Hcy level of trial group were increased significantly,compared with control group(P0.05).Multiple regression analysis revealed that the average CA-IMT was positively related to duration of therapy(P0.05),i.e.the longer duration of therapy was,the higher average CA-IMT was.CONCLUSIONS:The increase of CA-IMT is associated with epileptic patients receiving CBZ.It is necessary to determine regularly blood lipid and Hcy level of patients receiving CBZ therapy for a long time.
出处 《中国药房》 CAS CSCD 2013年第20期1879-1881,共3页 China Pharmacy
关键词 卡马西平 癫痫 颈总动脉内中膜厚度 血脂 同型半胱氨酸 Carbamazepine Epilepsy Carotid artery intima-media thickness Blood lipids Hcy
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参考文献10

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