摘要
目的:观察卡马西平(CBZ)对癫痫患者颈总动脉内中膜厚度的影响,并探讨其相关危险因素。方法:选取我院就诊的40例单一服用CBZ治疗时间大于1年的癫痫患者作为试验组,另选取40名健康志愿者作为对照组。分别测量受试者左、右两侧颈总动脉内中膜厚度(CA-IMT),计算平均CA-IMT(左、右两侧CA-IMT平均值),并检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及同型半胱氨酸(Hcy)等。对影响CA-IMT的相关危险因素(年龄、性别、体质量指数、病程、服药时间等)进行多元回归分析。结果:试验组双侧CA-IMT及平均CA-IMT均较对照组显著增加(P<0.001);试验组TC、TG、LDL-C、Hcy水平均较对照组显著升高(P<0.05)。多元回归分析结果显示,平均CA-IMT与服药时间呈正相关(P<0.05),即服药时间越长,患者平均CA-IMT越高。结论:服用CBZ的癫痫患者CA-IMT增加与服药时间有关,故长期服用CBZ的患者有必要定期检测血脂及Hcy。
OBJECTIVE:To observe the effects of carbamazepine(CBZ) on carotid artery intima media thickness(CA-IMT) in epileptic patients and its relative risk factors.METHODS:40 epileptic patients receiving CBZ alone more than 1 year were collected from our hospital as trial group,and other 40 healthy volunteers as control group.CA-IMT at both sides of common carotid artery were measured,and average CA-IMT(average value of CA-IMT at both sides of common carotid artery) was calculated.Blood lipid(TC,TG,LDL-C and HDL-C) and Hcy level were detected.Multivariable regression analysis were adopted to select the relative risk factors(age,gender,BMI,course of disease,duration of therapy,etc.) of CA-IMT.RESULTS:The CA-IMT of both sides and average CA-IMT were significantly increased in trial group,compared with control group(P0.001).TC,TG,LDL-C and Hcy level of trial group were increased significantly,compared with control group(P0.05).Multiple regression analysis revealed that the average CA-IMT was positively related to duration of therapy(P0.05),i.e.the longer duration of therapy was,the higher average CA-IMT was.CONCLUSIONS:The increase of CA-IMT is associated with epileptic patients receiving CBZ.It is necessary to determine regularly blood lipid and Hcy level of patients receiving CBZ therapy for a long time.
出处
《中国药房》
CAS
CSCD
2013年第20期1879-1881,共3页
China Pharmacy