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Thl7细胞在肿瘤中的作用 被引量：4

The role of Thl7 cells in tumor
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摘要 Thl7细胞是新发现的一群不同于Thl与Th2细胞的CD4＋T细胞亚群。Thl7细胞以IL-23依赖的方式分泌白细胞介素（IL）-17，在慢性炎症与自身免疫性疾病中发挥重要作用。自2005年发现以来，Thl7细胞受到了广泛关注，并已成为免疫学研究的热点。近年来的研究显示，Thl7细胞也参与了肿瘤免疫，但对于其是促进肿瘤发生发展还是抑制肿瘤发展尚无定论。 Thl7 ceils are recently identified as a novel CD4＋ T cell subset, which is different from Thl and Th2 lineage. Thl7 cells are characterized by the production of IL-17 in an IL-23 dependent way. Their involvement in chronic inflammation and autoimmune diseases has been confirmed. Since identified in 2005, Thl7 cells have been extensively investigated. Recent works have demonstrated that Thl7 cells participated in tumor immunity. However, whether these cells promote tumor growth or regulate antitumor responses remains controversial.
作者 臧梦雅 王冬梅 曲春枫
机构地区 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所分子肿瘤学国家重点实验室
出处 《国际免疫学杂志》 CAS 2013年第3期190-195,共6页 International Journal of Immunology
关键词 TH17细胞 白细胞介素-17 肿瘤免疫 Thl7 cells Interleukin-17 Tumor immunity
分类号 R730.3 [医药卫生—肿瘤]
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参考文献33

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同被引文献24

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引证文献4

二级引证文献24

国际免疫学杂志
2013年 第3期

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