采用不同治疗方法治疗高血压病合并冠心病的临床治疗效果比较研究

The Comparative Study for The Clinical Treatment Effect of Different Treatment Methods in the Treatment of Hypertensive Patients with Coronary Heart Disease

目的:比较不同治疗方案治疗高血压合并冠心病的临床疗效。方法:将本院收治的高血压合并冠心病患者随机分成3组,阿司匹林组采用氨氯地平联合阿司匹林方案,氯吡格雷组则采用氨氯地平联合氯吡格雷治疗,对照组仅口服氨氯地平。治疗6个月后,比较两种方案的降压疗效差异及左心室射血分数变化。结果:3种方案均能有效降压,降压总有效率均在90%以上,差异无统计学意义。三组治疗前左心室射血分数差异无统计学意义(P>0.05);治疗后第3、6个月,阿司匹林组和氯吡格雷组显著高于对照组(P<0.05),而氯吡格雷组的改善情况又显著优于阿司匹林组(P<0.05)。结论:氨氯地平能有效降低高血压病合并冠心病患者的血压,阿司匹林和氯吡格雷均具有改善心功能的作用,而两者中又以氯吡格雷为优。

Objective： To compare the clinical efficacy of different treatment regimens in the treatment of hypertension and coronary heart disease. Method： The hypertension and coronary heart disease patients admitted to our hospital were randomly divided into three groups： the Aspirin group was taken with amlodipine combined with aspirin program, the clopidogrel group was taken with amlodipine and clopidogrel, and the control group was only taken with oral amlodipine. After 6 months of treatment, the differences of antihypertensive efficacy in the two programs and left ventricular ejection fraction changes were compared. Result： The three programs were effective in buck, and the total effective rate of buck was 90%, there was no statistically significant difference between the two groups. The result of left ventricular ejection fraction was that the treatment was without significant differences between the three groups of patients （ P〉0.05 ） . 3 and 6 months after treatment, aspirin, and clopidogrel group was significantly higher than that in the control group （ P〈0.05 ）, while the improving situation of the elopidogrel group was significantly better than the aspirin group （ P〈0.05 ） . Conclusion： Amlodipine is effective in reducing blood pressure in hypertensive patients with coronary heart disease patients, aspirin and clopidogrel has a role in improving heart function. In the both two ways, clopidogrel is excellent.