马来酸依那普利联合辛伐他汀治疗老年高血压的效果观察

The Observation of the Effect for Enalapril Maleate Combined with Simvastatin in the Treatment of Elderly Patients with Hypertension

目的:观察马来酸依那普利联合辛伐他汀治疗老年高血压的效果。方法:将笔者所在医院收治的180例老年高血压患者随机分成对照组和观察组,各90例。对照组采用马来酸依那普利治疗,观察组则采用马来酸依那普利联合辛伐他汀方案,比较两种方案降压的疗效差异,治疗前及用药后12周两组患者的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等血清血脂变化。结果:治疗12周后,两种方案治疗高血压的总有效率达到了90.00%以上,组间比较差异无统计学意义(P>0.05),其中观察组显效率显著高于对照组(P<0.05)。治疗前两组患者的TG、TC、LDL-C、HDL-C均处于异常值范围,且在两组间不存在统计学差异;治疗12周后,观察组患者的各项指标均得到了显著改善,与对照组相比差异有统计学意义(P<0.05)。结论:马来酸依那普利联合辛伐他汀治疗老年高血压疗效优于马来酸依那普利单用,而且能有效改善老年患者的高血脂状态。

Objective： To observe the effect for enalapril maleate combined with simvastalin in the trealment of elderly palient~ with hypertensionMethods： 180 cases of elderly patients with hypertension were randomly divided into the control group and the observation group, 90 cases in each.The control group was taken with enalapril maleate treatment, and the observation group was taken with enalapril maleate combined with simvastatin.The differences of the step=down, triglyceride（TG）, total cholesterol（TC）, low-density lipoprotein（LDL-C）, high density lipoprotein（HDL-C） and other changes in serum lipids 12 weeks before and after treatment for the two groups of patients were compared.Results： After 12 weeks of treatment, the total efficiency rate for the two programs in the treatment of high blood pressure was 90.00%, the difference was not statistically significant between the two groups（P〉0.05）.The efficiency rate in the observation group was significantly higher than the control group（P〈0.05）.The TG, TC, LDL-C, HDL-C in the treatment group were all in the range of abnormal values, and there was no statistically significant difference between the two groups.（P〉0.05） After treatment of 12 weeks, the indicators in the observation group were with significant improvement. Compared to the control group, there was significant difference（P〈0.05）.Conclusion： The efficacy for enalapril maleate combined with simvastatin in the treatment of elderly patients with hypertension is better than only with enalapril maleate, and it can also improve elderly patients＇ state effectively.