胃疡宁丸对胃肠运动影响的研究

Experimental Study of the Effect of Weiyangning Pill on Gastrointestinal Motility

目的:研究胃疡宁丸对胃肠运动的影响。方法:将实验动物随机分为对照组、胃疡宁低、中、高剂量(0.395,0.79,1.58 g.kg-1)组、胃康宁组(0.4 g.kg-1)、吗丁啉组(0.05 g.kg-1),进行硫酸酮致家鸽呕吐实验,测定呕吐潜伏期和呕吐频率;进行大鼠在体肠运动实验、正常离体兔肠运动实验、乙酰胆碱所致痉挛离体兔肠运动实验,测定给药前后张力,并计算抑制率。结果:胃疡宁丸能够减少家鸽呕吐频率(P<0.05或P<0.01),抑制大鼠在体肠的收缩(P<0.01),并且对正常离体兔肠收缩与乙酰胆碱所致离体兔肠痉挛有明显抑制作用。结论:胃疡宁丸有胃肠解痉、止呕的作用与其抑制胃肠运动有关。

Objective： To research the effect of Weiyangning pill on gastrointestinal motility. Method： The experimental animal were randomized into control, Weiyangning pill low, medium and high dose （0.395, 0.79, 1.58 gkg-1） groups, Weikangning group （0.4 gkg-1）, domperidone group （0.05 gkg-1）. Pigeon vomiting experiment was used to determine the incubation period of vomiting and vomiting frequency. Intestinal motility in rat, normal isolated rabbit intestinal and inhibition of spasm induced by acetylcholine in isolated rabbit intestinal were employed to determine the muscle tension of intestine before and after administration then calculating the inhibition rate. Result： Weiyangning pill could reduce the frequency of pigeon vomiting, inhibit the contraction of in vivo intestinal, inhibit the contraction of normal isolated rabbit intestinal and inhibit the spasm induced by acetylcholine in isolated rabbit intestinal. Conclusion： Weiyangning pill can inhibit the gastrointestinal motility in experimental animals.