马来酸依那普利叶酸片对H型高血压患者血清瘦素水平的影响

Effects of Enalapril and Folic on Plasma Levels of Leptin in Patients with h-type Hypertension

目的:观察H型高血压患者血清瘦素变化及马来酸依那普利叶酸片(依叶)对其水平的影响。方法:76例高血压合并高同型半胱氨酸(Hcy)的H型高血压患者随机分为依叶组38例和依那普利组38例,分别予以口服依那普利叶酸片和依那普利片2月,另外选择40名同期健康体检者做对照。观察用药前后患者的血清瘦素、血压、血浆Hcy及左心室质量指数(LVMI)。结果:H型高血压患者血清瘦素水平[(15.83±3.75)μg.L-1]明显高于健康对照组[(7.35±2.17)μg.L-1],差异有统计学意义(P<0.01);随H型高血压分级的增加瘦素水平逐渐升高(P<0.05);治疗后,依叶组和依那普利组患者血压均得到有效的控制,血清瘦素水平及LVMI明显下降,但依叶组更为明显(P<0.05)。结论:血清瘦素可以作为判断H型高血压严重程度的指标;依叶片较依那普利更能有效降低血清瘦素水平,改善心肌肥厚。

Objective： To explore the changes in serum leptin level in the patients with h-type hypertension and to observe the efficacy of Enalapril and folic on the serum levels of leptin in patients with h-type hypertension. Method： Seventy-six patients with h-type hypertension were randomly divided into two groups： the enalapril maleate folic Acid tablet group （n=38） and the enalapril group （n=38）, and selected 40 healthy person as control group. Serum leptin,BP,and plasma Hcy and left ventricular mass index（LVMI） were analysed the first 24 hours after admission and 2 mouths after treatment. Result： Serum leptin in h-type hypertension patients[（15.83±3.75）μgL-1] was significantly higher than that of the controls [（7.35±2.17）μgL-1]; the serum leptin increased with the increase of degree of h-type hypertension（P〈0.05）; after 2 mouths＇ treatment, controlled blood pressure, and decreased serum leptin and LVMI were seen in both the enalapril maleate folic acid tablet group and the enalapril group,significane was found in enalapril maleate folic acid tablet group（P〈0.05）. Conclusion： The level of serum leptin is avaluable negative index to indicate the severity of heart failure. Enalapril with folic acid tablets has a better effect on lower the serum leptin and improve myocardial hypertrophy.