乳腺癌耐药蛋白与糖尿病

Breast Cancer Resistance Protein and Diabetes

糖尿病是一种常见的全身性慢性代谢障碍性疾病。在糖尿病状态下,不仅细胞色素P450酶会发生改变,也伴随着许多ABC外排转运体的变化。乳腺癌耐药蛋白(breast cancer resistance protein,BCRP)是一种重要的ABC外排转运体,在大多数组织和器官中都有表达,发挥对机体组织的保护作用。糖尿病患者体内BCRP表达和活性会发生改变,通过作用于药物的吸收和外排,影响药物的疗效。因此,BCRP表达和活性的改变在糖尿病的治疗进程中有着重要的作用。本文就糖尿病状态下BCRP表达和功能的改变及引起这些改变的相关影响因素做一综述,以期为糖尿病研究和治疗提供新思路。

Diabetes is a group of systematic metabolic diseases.In addition to cytochromes P450s,some ATP-binding cassette drug transporters are also under diabetic conditions.Breast cancer resistance protein(BCRP),an important member of ATP-binding cassette drug transporters,expressed in most of the tissues,is thought to play an important protective role in normal tissues.It was reported that BCRP function and expression were impaired in intestine of diabetes rats,which affects the absorption and efflux of some drugs.Therefore,the alteration of BCRP expression and activity could be of critical importance for the treatment of diabetes mellitus.In this article,we reviewed the relationship between diabetes and BCRP in order to provide some new ideas for the study of diabetes.