红树植物木榄胚轴中苯丙素类化学成分研究

Study on phenylpropanoids from hypocotyls of the mangrove plant Bruguiera gymnorrhiza

从木榄胚轴中分离出7个苯丙素类化合物,运用波谱学确定了化合物结构,分别鉴定为莨菪亭(1)、Balanophonin(2)、开环异落叶松脂素(3)、臭失菜素A(4)、松脂素(5)、5'-甲氧基-(-)-松脂素(6)、Lyoniresinol-3α-O-β-D-glucopyranosides(7)。化合物1,3,7对肿瘤细胞株A549显示出弱抑制活性,IC50值分别为290.2、323.0、209.3μg/mL。除化合物3和5以外,其他化合物均首次从该植物中分离得到。

Seven phenylpropanoids were isolated from the hypocotyls of Bruguiera gymnorrhiza and purified by re- peated column chromatography on silica, Sephadex LH-20 gel, and HPLC and structurally identified by spectral anal- ysis. The compounds were identified as Scopoletin（1） ,Balanophonin（2） ,Secoisolariciresinol（3） ,Cleomiscosin A（4）, Pinoresinol（5） ,Medioresinol（6） ,and Lyoniresinol-3a-O-β-D-glucopyranosides（7）. Anti-tumors activity bioassay indi- cated that compounds 1,3 and 7 had weak cytotoxicity toward human cancer cell lines A549 with ICso of 290. 2, 323.0, and 209.3 vg/mL, respectively. All compounds were isolated from this plant for the first time except 3 and 5.