马钱科植物钩吻(Gelsemium elegans)的化学研究

Chemical Studies on Alkaloids from Gelsemium elegans

研究钩吻(Gelsemium elegans)根茎的化学成分。采用色谱方法进行分离纯化,通过理化及波谱鉴定化学结构。经钩吻甲醇提取物的酸碱处理后的总碱分离得到13个生物碱,分别为五种结构类型,3个Sarpagine-type生物碱:Gardnerine(1),Koumidine(2),N-methoxyanhydrovo-basinediol(3);3个Humantenine-type生物碱:Humantenine(4),Humantenirine(5),Rankinidine(6),3个Gelsedine-type生物碱:Gelsedine(7),Gelsenicine(8),19-Oxo-gelsenicine(9),2个Koumine-type生物碱:Koumine(10),19S-Kouminol(11);2个Gelsemine-type生物碱:Gelsemine(12),Gelesevirine(13).这五种类型构成钩吻生物碱的基础生源途径。

The chemical constituents of Gelsemium elegans were studied. 13 alkaloids were isolated by column chromatography ,while their structures were identified on the basis of spectroscopic date. Including 3 of Sarpagine-type alkaloids： Gardnerine （ 1 ） , Koumidine （ 2 ） , N-methoxyanhydrovo-basinediol （ 3 ）. 3 of Humantenine-type alkaloids ： Humantenine （4）, Humantenirine （ 5 ）, Rankinidine （ 6 ）. 3 of Gelsedine-type alkaloids ： Gelsedine （7） , Gelsenicine （ 8 ） , 19-Oxo-gelsenicine （9）. 2 of Koumine-type alkaloids ： Koumine （ 10 ）, 19S-Kouminol （ l 1 ）, 2 of Gelsemine-type alkaloids ： Gelsemine （ 12）, Gelesevirine （ 13 ） relatively, which constitute the basic biogenetic pathway of Gelsemium alkaloids.