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厄贝沙坦对老年高血压患者脉压的影响

Influence of irbesartan on pulse pressure in elderly patients with essential hypertension.
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摘要 目的:探讨厄贝沙坦对老年高血压患者脉压的影响。方法:选择1~2级老年高血压患者49例,给予厄贝沙坦80mg/天口服,共6个月。观察患者治疗前后脉压、收缩压、舒张压变化和药物的不良反应。结果:与治疗前相比,治疗后患者的脉压缩小(P<0.001)、收缩压和舒张压明显下降(P<0.001),无明显不良反应。结论:厄贝沙坦能缩小老年高血压患者的PP,有效、安全降低血压,从而抗动脉粥样硬化。 Objective: To investigate the influences of irbesartan on Pulse Pressure (PP) in elderly patients with essential hyper- tensine. Methods: 48 elderly patients with essential hypertension were treated with irbesartan 80mg/d for 6 months. The PP were de- tected before and after treatment, as well as systolic blood pressure (SBP) and diastolic blood pressure (DBP). The side effects of irbesartan were observed also. Results: After 6 months of treatment with irbesartan , the PP decreased significantly ( P 〈 0. 01 ), the SEP and DBP decreased significantly (P 〈0. 01 ), and there were no side effects of irbesartan during treatment. Conclusion: irbesartan can decline PP in elderly patients with essential hypertension , lower blood pressure effectively.
作者 王毅
出处 《中国民族民间医药》 2013年第7期100-100,102,共2页 Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词 厄贝沙坦 老年 高血压 脉压 Irbesartan Essential hypertension Elderly Pulse pressure (PP)
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  • 1吴兆苏,中华心血管病杂志,1997年,25卷,255页
  • 2吴兆苏,中华心血管病杂志,1997年,25卷,6页
  • 3Wolny A,Clozel JP,Rein J,et al.Functional and biochemical analysis of angiotensin Ⅱ-forming pathways in the human heart[J].Circ Res,1997,80(2):219-217.
  • 4de Gasparo M,Catt KJ,Inagami T,et al.International Union of Pharmacology.XXⅢ.The angiotensin Ⅱreceptor[J].Pharmacol Rev,2000,52:415-472.
  • 5Lucius R,Gallinat S,Busche S,et al.Beyond blood pressure:new roles for angiotensin Ⅱ[J].Cell Mol Life Sci,1999,56:1008-1019.
  • 6Stergiou GS,Skeva II.Renin-angiotensin system blockade at the level of the angiotensin converting enzyme or the angiotensin type-1 receptor:similarities and difference[J].Curr Top Med Chem,2004,4(4):473-481.
  • 7Unger T,Culman J,Gohike P.Angiotensin Ⅱ receptor blockade and end-organ protection:pharmacological rationale and evidence[J].J Hypertens,1996,14(suppl 7):s3-s9.
  • 8Nio Y,Matsubara H,Murasawa S,et al.Regulation of gene transcription of angiotensin Ⅱreceptor subtypes in myocardial infarction[J].J Clin Invest,1995,95:46-45.
  • 9Munzenmaier DH,Greene AS.Opposing actions of angiotensin Ⅱ on microvascular growth and arterial blood pressure[J].Hypertension,1996,27:760-765.
  • 10Busche S,Gallinat S,Bohle RM,et al.Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction.A single-cell reverse transcriptase-polymerase chain reaction study [J].Am J Pathol,2000,157:605-611.

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