重组人生长激素联用丹参注射液治疗重症烧伤的临床研究

The Clinical Study of Effect of Recombinant Human Growth Hormone Combined with Danshen Injection in Severely Burned Patients

目的评价重组人生长激素联合丹参注射液对重症烧伤的临床治疗效果。方法将120例严重烧伤患者,随机分为A组(观察组)和B组(对照组),每组60例。A组静脉滴注丹参注射液,B组注射相同体积的等渗盐水;两组给予皮下注射0.1mg/(kg d)重组人生长激素治疗。疗程为14d。监测并记录两组患者的蛋白代谢及糖代谢,内毒素(LPS)、肿瘤坏死因子α(TNF-α)以及白细胞介素(IL-6)水平。结果治疗后7d与14d,观察组血红蛋白及血浆总蛋白均高于对照组,差异具有统计学意义(P<0.05);治疗后7d与14d,观察组LPS(脂多糖),TNF-α,IL=6均显著低于对照组(P<0.05)。结论重组人生长激素联用丹参注射液对重症烧伤患者可发挥一系列的治疗作用,如促进蛋白质合成,抑制炎性反应,提高患者的免疫功能,降低患者感染率,进而可缩短患者的住院时间。治疗效果稳定可靠,优于单用重组人生长激素治疗。

Objective To evaluate the clinical efficacy of recombinant human growth hormone combined with Danshen injection in severely burned patients. Methods 120 cases of severely burned patients were randomLy divided into A group （rbGH and D.I. group） and B group （control group）. Patients in group A were given Danshen injection and patients in group B the same volume of normal saline. Both groups were treated with rhGH injection [0.1mg/（kg·d）, subcutaneous injectionl. The treatment lasted for 14 days. Protein metabolism, glucose metabolism, LPS, TNF-α, IL-6 were assayed and compared between two groups. Results Compared with patients in group B, those in group A had significantly higher protein content and remarkably lower LPS, TNF-α and IL-6 （P〈0.05） . Conclusions The therapy of recombinant human growth hormone combined with Danshen Injection can treat severely burned patients in a number of ways： promoting protein synthesis, inhibiting inflammation, enhancing immunological function and reducing infection. The combined therapy is superior to rhGH therapy and can achieve better efficacy.