山莨菪碱,间苯三酚分别联合双氯芬酸钠利多卡因,异丙嗪治疗肾绞痛的效果比较

Comparative Effectiveness Research on Renal Colic therapy with Combined Usage of Anisodamine, Phloroglucinol and Diclofenac Sodium Lidocaine, Promethazine Respectively

目的观察山莨菪碱,间苯三酚分别联合双氯芬酸钠利多卡因,异丙嗪治疗肾绞痛的疗效及安全性。方法将我科自2010年7月至2012年6月488例明确诊断为结石性肾绞痛的患者,分成4个治疗组,分别为山莨菪碱注射液加双氯芬酸钠利多卡因注射液治疗组(A组)、间苯三酚注射液加双氯芬酸钠盐酸利多卡因治疗组(B组)、山莨菪碱加异丙嗪注射液治疗组(C组)、间苯三酚加异丙嗪治疗组(D组),于治疗后30min、60min观察不同组间的止痛效果,副作用及24h复发率。结果 A组总有效率92.0%,B组总有效率96.3%,C组总有效率93.2%,D组总有效率95.1%;A组副作用发生率11.7%,B组副作用发生率5%,C组副作用发生率12.5%,D组副作用发生率8.7%;A组24h复发率10.2%,B组24h复发率7.5%,C组24h复发率9%,D组24h复发率8.7%。结论 B组镇痛效果好,副作用少,24h复发率低。

Objective To evaluate the efficacy and safety of combination therapy of renal colic using anisodamine, phloroglucinol and diclofenac sodium lidocaine, promethazine respectively. Method 488 patients who were definitely diagnosed with renal colic caused by calculus in our department from July 2010 to June 2012 are divided into four treatment groups. Group A is treated with anisodamine and diclofenac sodium lidocaine injection. Group B receives phloroglucinol injection and diclofenac sodium and lidocaine hydrochloride treatment. Group C uses anisodamine and promethazine injection. Group D uses phloroglucinol and promethazine. Analgesic effect, side effect and 24h recurrence rate will be observed among different groups 30 mins and 60 mins after treatment. Results It is found that total effective rates of group A, B, C and D are 92.0%, 96.3%, 93.2% and 95.1% respectively; incidences of side effects are 11.7%, 5%, 12.5% and 8.7% respectively; 24h recurrence rates are 10.2%, 7.5%, 9% and 8.7% respectively. Conclusion It is concluded that group B is with better analgesic effect, less side effects and lower 24h recurrence rate.