肝癌病理学微浸润距离研究

Study on the microinvasive distance in the primary carcinoma of the liver

目的本研究通过MIAS显微测量肝癌微浸润距离,确定影像学包膜完整的肝癌微浸润距离,为放射治疗时GTV的外放CTV提供依据。方法收集23例在我院行肝癌切除术的影像学包膜完整的原发性肝癌患者的肝脏标本。制作成病理切片,观察肝癌微浸润。采用MIAS病理图文系统测量微浸润灶的距离。结果 91%(21/23)的肝癌有微浸润。微浸润距离为0.36～4.45mm,平均值(2.51±0.75)mm。肝癌微浸润距离与患者年龄、肿瘤直径等常用临床指标无关。结论影像学包膜完整的肝癌多数存在微浸润。GTV外扩4mm可以包括95%肝癌微浸润病灶。

Objective To detect the microinvasive distance of primary carcinoma of the liver by MIAS. Methods A to- tal of 23 patients with histologically verified of the primary carcinoma of the live who had undergone hepatectomy. The microinva- sive distance was detected by MIAS. Results The microinvasive was observed in 91% （21/23）patients and the distance was 0. 36± 4. 45mm. The mieroinvasive distance didn＇t relative to age and the tumor size of tumor. Conclusion 91% patients with integrated envelope had microinvasive. The distance expanded 4mm from GTV included 95% microinvasive cancer cell.