辣椒碱软膏及美洛昔康治疗双膝骨关节炎疗效临床观察

Clinical observation on treating knee ostearthritis with capsaicin ointment and meloxicam

目的观察辣椒碱软膏及美洛昔康治疗双膝骨关节炎的疗效及安全性。方法 69例符合美国风湿病学院(ACR)双膝骨关节炎诊断标准患者随机分配进入辣椒碱软膏联合美洛昔康组(A组)、单用辣椒碱软膏组(B组)、单用美洛昔康组(C组)。A组使用0.025%辣椒碱软膏均匀涂抹双膝关节,3次/d,同时服用美洛昔康1片(7.5mg),2次/d;B组使用0.025%辣椒碱软膏均匀涂抹双膝关节,3次/d;C组服用美洛昔康1片(7.5mg),2次/d,疗程均为2周。结果①三组方案在20mm步行痛、关节触痛疼痛程度、WOMAC骨关节炎指数C等指标方面均有改善。②A组明显优于B组与C组,P<0.05。③B组与C组相比差异无统计学意义。结论辣椒碱软膏及美洛昔康对双膝骨关节炎安全有效,联合应用优于单独使用。

Objective To investigate the efficacy and safety of topical capsaicin ointment and meloxicam in treating knee ostearthritis. Methods Sixty-nine patients fulfilling the American College of Rheumatology criteria for knee OA were randomly di- vided into three groups： group A were given capsaiein ointment applied to the skin about the knee 3 times a day and meloxicam 7. 5mg 2 times a day; group B were given capsaicin ointment applied to the skin about the knee 3 times a day; group C were given meloxieam 7.5mg 2 times a day for 2 weeks. Results ①The significant changes were observed in the three groups in 20mm walking pain ,joint pain and 20mm walking pain, WOMAC Osteoarthritis Index C ;②The treatment for group A was more effective than those for groups B and C（ P 〈 0.05 ） ;③There were no significant differences between group B and C （ P 〉 0. 05 ）. Conclu- sion The topical capsaicin ointment and meloxicam can provide effective and safe for the treatment of knee ostearthritis, the treat- ment for joint capsaiein ointment and meloxicam was superior to capsaicin ointment or meloxicam alone.