血清胃蛋白酶原 癌胚抗原在胃癌诊断中的临床意义

Clinical evaluation of pepsinogens and carinoembryonic antigen applied in the diagnosis of gastric cancer

目的研究血清胃蛋白酶原(PG)Ⅰ、Ⅱ,癌胚抗原(CEA)及PGⅠ/Ⅱ含量变化与胃癌发生的关系,探讨其在胃癌早期诊断中的临床价值。方法采用电化学发光法检测75例胃癌患者,86例良性胃病对照组,101名健康对照组血清CEA水平,免疫比浊法测定PGⅠ、Ⅱ,并计算PGⅠ/Ⅱ比值。结果胃癌患者血清CEA水平检测明显高于健康对照组,差异有统计学意义(P<0.01)。胃癌组PGⅠ、Ⅱ及比值明显低于良性胃病对照组(P<0.01),联合检测灵敏度显著提高(P<0.05)。结论血清PGⅠ、Ⅱ及比值下降并且CEA水平不同程度升高与胃癌发生密切相关,联合检测有助于提高胃癌诊断的灵敏度和特异度,对胃癌的早期诊断具有重要的临床意义。

Objective To study the relationship between the serum pepsinogen I/II , carcinoembryonic antigen （CEA） and I/II content＇s changes and gastric cancer, explore its clinical value in early diagnosis of gastric cancer. Methods Using electrochemical luminescence method to detect serum CEA level of 75 cases of patients with gastric cancer, 86 cases of benign gastric disease control group, 101 cases of healthy controls, immune turbidimetric determination of pepsinogen I , II , and calculates the I /II ratio. Results Serum CEA level in gastric cancer patients was significantly higher than healthy control group （P〈0.05）. Gastric cancer group of pepsinogen I /II ratio significantly lower than benign stomach disease control group （P〈0.01）, the joint detection sensitivity significantly increased （P〈0.05）. Conclusion For patients with gastric cancer pepsinogen I / II ratio fall and CEA in serum level rise in different level is closely related to gastric cancer. Joint testing helps to improve the sensitivity and specificity of diagnosis of gastric cancer, early diagnosis of gastric cancer has important clinical significance.