坎地沙坦联合胺碘酮治疗高血压病合并持续性房颤的临床疗效分析

Study on effect of candesartan cilexetil combined with amiodarone in treatment of senile hypertension complicated with persistent atrial fibrillation

目的探讨坎地沙坦联合胺碘酮治疗高血压病合并持续性房颤的临床效果。方法病例选取2010年8月至2012年8月在心内科诊断治疗的64例高血压病合并持续性房颤患者,随机分为两组,每组32例。对照组仅用胺碘酮,治疗组在对照组的基础上加用坎地沙坦,连续用药3个月,观察两组的治疗效果。结果治疗组在转复时间、转复率、复发率及左心房功能恢复方面明显优于对照组,两组比较差异有统计学意义(P<0.01)。结论坎地沙坦联合胺碘酮对高血压合并持续性房颤有较好地临床治疗作用。

Objective To explore the therapeutic effect of candesartan cilexetil combined with amiodarone in treatment of patients with senile hypertension complicated with persistent atrial fibrillation. Methods The clinical data of 64 patients with senile hypertension complicated with persistent atrial fibrillation in this department during August 2010 to August 2012 were retrospectively analyzed, they were randomly divided into trial group and control group, each group with thirty - two patients. Patients in control group were only treated by amiodarone, and patients in trial group were added with candesartan cilexetil. Their curative effects were evaluated after treatment for 3 months. Results The rate of reversion, duration for reversion, relapse rate and recovery of left atrial function in patients of trial group were markedly higher in comparison to those of patients in control group （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Candesartan cilexetil combined with amiodarone has good clinical efficacy in treatment of patients with senile hypertension complicated with persistent atrial fibrillation.