肾移植术后急性排斥反应中血清半胱氨酸蛋白酶抑制剂C和C-反应蛋白水平的变化及意义

The changes and clinical significance of serum Cystatin C and CRP levels in acute rejection after renal transplantation

目的探讨血清胱抑素C(Cys C)和C-反应蛋白(CRP)在肾移植术后急性排斥反应过程中的变化及意义。方法采用免疫速率散射比浊法分别检测80例健康人、86例肾移植患者术前、急性排斥反应组及肾功能稳定组血清Cys C和CRP的浓度。结果急性排斥反应组和肾功能稳定组血清Cys C和CRP水平均明显高于正常对照组。尽管与术前相比,二者血清Cys C和CRP水平均明显降低,但急性排斥反应组血清Cys C和CRP水平均明显高于肾功能稳定组。结论 Cys C和CRP可做为辅助诊断肾移植术后急性排斥反应发生的免疫生物学指标。

Objective To investigate the change and clinical significance of Cystatin C and CRP levels in acute rejection after renal trans- plantation. Methods Immuoturbidmetric method was applied for detecting Cystatin C and CRP levels of 80 normal subjects and 86 cases of patients before renal transplantation, acute rejection and stable renal function. Results Serum Cystatin C and CRP levels in acute rejection and stable renal function patients were obviously higher than that in control group （ P 〈0.01 ）, which were significantly lower compared with that of before renal transplantation （ P 〈0.01）. However, Serum Cystatin C and CRP levels in acute rejection patients were obviously higher than that in patients with stable renal function （ P 〈 0.01 ）. Conclusion Cystatin C and CRP can be used as immunobiologic markers for adjuvant diagnosis of acute rejection after renal transplantation.