剖宫产对产妇和新生儿体内NK细胞含量影响的研究

Impact of cesarean delivery on the number of maternal and neonatal NK cells

目的研究剖宫产对产妇和新生儿体内自然杀伤细胞(NK细胞)数量的影响。方法选取足月分娩的产妇90例,按照分娩方式不同,分为自然分娩组、择期剖宫产组和临产后剖宫产组,每组30例。分别取分娩时的新生儿脐血和产妇外周血检测NK细胞的百分数,并统计新生儿发生感染的概率。结果三组产妇NK细胞百分数比较差异无统计学意义(P>0.05),择期剖宫产组新生儿血中NK细胞百分数明显低于其他两组,且与正常分娩组比较差异有统计学意义(P<0.05),且该组新生儿具有较高的感染发生率(20%),明显高于其他两组(P<0.05)。结论刨宫产对产妇血中NK细胞数没有影响,而择期剖宫产可以减少新生儿血中NK细胞数,增加新生儿感染发生率,表明此类新生儿免疫功能降低。

Objective To study the impact of cesarean delivery on NK cells number in maternal and neonatal. Methods Ninety cases of parturients were selected and divided into group of natural childbirth （n = 30）, elective caesarean section （n = 30） and caesarean section after labor （ n = 30）. Neonatal cord blood and maternal peripheral blood were collected to detect the percentage of NK cells. Results NK cell percentage of parturient in three groups exhibited no significant difference （ P 〉 0.05 ）. Neonatal blood NK cell percentage in elective cesarean section group was significantly lower than the normal delivery group （ P 〈 0.05 ） ; and the neonatal infection probability of elective cesarean section group was 20%, significantly higher than the other two groups （ P 〈 0.05 ）. Conclusion The elective cesarean section delivery reduces the number of NK cells in the blood of newborns, that indicates low immunity status in these newborns.