核转录因子-κB对中枢神经系统学习记忆的影响

Effect of Nuclear Transcription Factor-κB on Learning and Memory of Central Nervous System

核转录因子-κB在中枢神经系统的神经细胞内广泛存在,与细胞浆内IκB结合处于静息状态,当接受刺激信号后,脱离IκB的限制激活进入细胞核内。神经元突触末稍的核转录因子-κB被激活后可转录启动下游靶基因的表达,参与学习记忆过程,与记忆的构建、记忆巩固和记忆重建具有密切关系。

Nuclear transcription factor - kappa B （ NF -κB ） is an inducible transcription factor widely present in central nervous system, sequestering in the cytoplasm as an inactive complex with IκB inhibitory protein. When being stimulated, it will be activated and free to the nucleus. NF-κB plays an important role in transduction of signals from synaptic terminals to nucleus so as to initiate transcriptional responses and expression of downstream target genes. It involves in the process of learning and memory, and is closely related to memory formation, consoli- dation and reconsolidation.