血清肌钙蛋白I在放射性心脏损伤中的变化及右丙亚胺对其影响

The Change of Serum Troponin I in Radiation-induced Heart Injury and the effects of Dexrazoxane

目的:探讨血清肌钙蛋白I(cTn-I)在放射性心脏损伤中的变化及右丙亚胺对其影响。方法:将健康雄性Wistar大鼠50只随机分为正常对照组(C组)、单纯照射组(R组)、右丙亚胺防护组(F组)。R组和F组大鼠给予心前区20Gy X线照射一次,F组于照射前30min给予右丙亚胺125mg/kg腹腔注射,照射后给予右丙亚胺50mg/kg腹腔注射,每周1次,直至实验结束,其余两组腹腔注射等量生理盐水。照射后1、2、4、8周ELISA法测定血清cTn-I。结果:R组大鼠照射后1、2、4、8周血清cTn-I均较C组显著升高(P<0.001),F组血清cTn-I均较R组对应时间点显著降低(P<0.001)。结论:心脏放射性损伤时血清cTn-I明显升高,右丙亚胺可减轻这种变化。

Objective：To investigate the change of serum troponin I in radiation-induced heart injury and observe the effects of dexrazoxane. Methods：50 healthy male Wistar rats were divided into 3 groups randomly： the healthy control group （C）, the radiation group（R）and dexrazoxane protection group（F）. Rats of group C and R were irradiated in precordium by X- ray which does was 20 Gy,Each rat of group F was given an intraperitoneal injection of dexrazoxane（125 mg/kg） 30 minutes before irradiation and an intraperitoneal injection of dexrazoxane（50 mg/kg） once a week after irradiation till the end of the experiment,and all the rest rats were inject the same volume of saline. The serum troponin I were detected in 1,2,4 and 8 week after irradiation. Results：On 1,2,4 and 8 week,the content of cTn-I in group R increased significantly than group C（ P 〈0. 001）,and the content of cTn-I in group F decreased significantly than group R（ P 〈0. 001）. Conclusion：The content of serum cTn-I increased obviously and dexrazoxane can alleviate this change.